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Ctnnd1 Gene Detail
Summary
  • Symbol
    Ctnnd1
  • Name
    catenin delta 1
  • Synonyms
    catenin (cadherin associated protein), delta 1, Catns, Ctnnd, mKIAA0384, P120, p120-catenin
  • Feature Type
    protein coding gene
  • IDs
    MGI:105100
    NCBI Gene: 12388
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84430415-84481109 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    966 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105100
 protein coding gene Chr2:84417440-84489321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025900
 protein coding gene Chr2:85281973-85333245 (-)
A/J MGP_AJ_G0025874
 protein coding gene Chr2:81976100-82026775 (-)
AKR/J MGP_AKRJ_G0025844
 protein coding gene Chr2:84090069-84143824 (-)
BALB/cJ MGP_BALBcJ_G0025871
 protein coding gene Chr2:82113645-82164711 (-)
C3H/HeJ MGP_C3HHeJ_G0025630
 protein coding gene Chr2:84339093-84392839 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026317
 protein coding gene Chr2:87923453-87973934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023719
 protein coding gene Chr2:78810767-78863078 (-)
CAST/EiJ MGP_CASTEiJ_G0025091
 protein coding gene Chr2:84850923-84911606 (-)
CBA/J MGP_CBAJ_G0025611
 protein coding gene Chr2:91067956-91125012 (-)
DBA/2J MGP_DBA2J_G0025742
 protein coding gene Chr2:81522977-81573912 (-)
FVB/NJ MGP_FVBNJ_G0025705
 protein coding gene Chr2:80764127-80817593 (-)
LP/J MGP_LPJ_G0025830
 protein coding gene Chr2:85080347-85134926 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025735
 protein coding gene Chr2:93380185-93460533 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026373
 protein coding gene Chr2:84318757-84370330 (-)
PWK/PhJ MGP_PWKPhJ_G0024835
 protein coding gene Chr2:81355046-81407369 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024639
 protein coding gene Chr2:84473078-84524210 (-)
WSB/EiJ MGP_WSBEiJ_G0025161
 protein coding gene Chr2:84995413-85046667 (-)



Homology
more
  • Human Ortholog
    CTNND1, catenin delta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNND1, catenin delta 1
  • Synonyms
    BCDS2, CAS, CTNND, p120, p120(CAS), P120CAS, p120(CTN), P120CTN
  • Links
    NCBI Gene ID: 1500
    neXtProt AC: NX_O60716
    UniProt: O60716

  • Chr Location
    11q12.1; chr11:57753243-57819546 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CTNND1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 2 alleles in 5 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene die shortly after birth and have morphological abnormalities of the salivary glands and lacrimal gland.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    124
  • cDNA Data
    277
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034101 Ensembl Gene Model | MGI Sequence Detail 50695 C57BL/6J ±  kb
    transcript ENSMUST00000111694 Ensembl | MGI Sequence Detail 6362 Not Applicable  
    polypeptide ENSMUSP00000107323 Ensembl | MGI Sequence Detail 967 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 282
      Genomic 1
      cDNA 277
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-28063, MGD-MRK-32140, MGI:2138768, MGI:2139175
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 57
      Gene Ontology 24
      Phenotypes 47
    • Earliest
      J:29846 Reynolds AB, et al., p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene. 1992 Dec;7(12):2439-45
    • Latest
      J:354189 Miao L, et al., beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation. Cardiovasc Res. 2024 Sep 21;120(11):1279-1294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory