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Cbx1 Gene Detail
Summary
  • Symbol
    Cbx1
  • Name
    chromobox 1
  • Synonyms
    Cbx-rs2, E430007M08Rik, HP1B, Hp1beta, M31, MOD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105369
    NCBI Gene: 12412
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96679953-96699466 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.11 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    463 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105369
 protein coding gene Chr11:96679506-96699808 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019012
 protein coding gene Chr11:99136399-99163249 (+)
A/J MGP_AJ_G0018980
 protein coding gene Chr11:95077175-95098498 (+)
AKR/J MGP_AKRJ_G0018950
 protein coding gene Chr11:98022720-98046179 (+)
BALB/cJ MGP_BALBcJ_G0018953
 protein coding gene Chr11:95577544-95597726 (+)
C3H/HeJ MGP_C3HHeJ_G0018767
 protein coding gene Chr11:98152295-98172271 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019405
 protein coding gene Chr11:102221366-102241723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017035
 protein coding gene Chr11:92559746-92580420 (+)
CAST/EiJ MGP_CASTEiJ_G0018320
 protein coding gene Chr11:98988927-99010186 (+)
CBA/J MGP_CBAJ_G0018738
 protein coding gene Chr11:106402265-106425844 (+)
DBA/2J MGP_DBA2J_G0018846
 protein coding gene Chr11:94640658-94661036 (+)
FVB/NJ MGP_FVBNJ_G0018835
 protein coding gene Chr11:94118891-94139436 (+)
LP/J MGP_LPJ_G0018916
 protein coding gene Chr11:99659939-99681134 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018862
 protein coding gene Chr11:106363439-106384349 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019445
 protein coding gene Chr11:98325817-98348159 (+)
PWK/PhJ MGP_PWKPhJ_G0018092
 protein coding gene Chr11:95608932-95629149 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017881
 protein coding gene Chr11:98056715-98078543 (+)
WSB/EiJ MGP_WSBEiJ_G0018370
 protein coding gene Chr11:98233340-98256212 (+)



Homology
more
  • Human Ortholog
    CBX1, chromobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBX1, chromobox 1
  • Synonyms
    CBX, HP1-BETA, Hp1beta, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
  • Links
    NCBI Gene ID: 10951
    neXtProt AC: NX_P83916
    UniProt: P83916

  • Chr Location
    17q21.32; chr17:48070052-48101478 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    153
  • cDNA Data
    101
  • Literature Summary
    21
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018666 Ensembl Gene Model | MGI Sequence Detail 19514 C57BL/6J ±  kb
transcript ENSMUST00000093943 Ensembl | MGI Sequence Detail 1251 Not Applicable  
polypeptide ENSMUSP00000091475 Ensembl | MGI Sequence Detail 185 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 107
    Genomic 1
    cDNA 102
    Primer pair 3
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-1790, MGD-MRK-33038, MGI:2442882
References
more
  • Summaries
    All 107
    Developmental Gene Expression 21
    Gene Ontology 18
    Phenotypes 26
  • Earliest
    J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory