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Rab5a Gene Detail
Summary
  • Symbol
    Rab5a
  • Name
    RAB5A, member RAS oncogene family
  • Synonyms
    2410015H04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:105926
    NCBI Gene: 271457
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:53786262-53814706 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 27.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    604 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105926
 protein coding gene Chr17:53786262-53814708 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023887
 protein coding gene Chr17:55033178-55061353 (+)
A/J MGP_AJ_G0023847
 protein coding gene Chr17:53480609-53508718 (+)
AKR/J MGP_AKRJ_G0023815
 protein coding gene Chr17:54113538-54142818 (+)
BALB/cJ MGP_BALBcJ_G0023849
 protein coding gene Chr17:53367521-53394738 (+)
C3H/HeJ MGP_C3HHeJ_G0023612
 protein coding gene Chr17:54839388-54867316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024293
 protein coding gene Chr17:57157332-57189196 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021741
 protein coding gene Chr17:50091148-50118153 (+)
CAST/EiJ MGP_CASTEiJ_G0023094
 protein coding gene Chr17:55148579-55176006 (+)
CBA/J MGP_CBAJ_G0023588
 protein coding gene Chr17:59282450-59315257 (+)
DBA/2J MGP_DBA2J_G0023717
 protein coding gene Chr17:52253057-52281983 (+)
FVB/NJ MGP_FVBNJ_G0023683
 protein coding gene Chr17:51884861-51917249 (+)
LP/J MGP_LPJ_G0023797
 protein coding gene Chr17:55738637-55766823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023711
 protein coding gene Chr17:58711757-58738814 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024338
 protein coding gene Chr17:54425178-54453676 (+)
PWK/PhJ MGP_PWKPhJ_G0022839
 protein coding gene Chr17:51718408-51754275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022653
 protein coding gene Chr17:51346599-51373257 (+)
WSB/EiJ MGP_WSBEiJ_G0023158
 protein coding gene Chr17:55092080-55120894 (+)



Homology
more
  • Human Ortholog
    RAB5A, RAB5A, member RAS oncogene family
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB5A, RAB5A, member RAS oncogene family
  • Synonyms
    RAB5
  • Links
    NCBI Gene ID: 5868
    neXtProt AC: NX_P20339
    UniProt: P20339

  • Chr Location
    3p24.3; chr3:19947097-19985175 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    21
  • cDNA Data
    21
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 271457 NCBI Gene Model | MGI Sequence Detail 28445 C57BL/6J ±  kb
    transcript NM_025887 RefSeq | MGI Sequence Detail 2364 ZRU/MplStud  
    polypeptide Q9CQD1 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33604, MGI:1914237, MGI:2146915, MGI:2146988
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 20
      Gene Ontology 37
      Phenotypes 16
    • Earliest
      J:18627 Bucci C, et al., Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5061-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory