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Trim21 Gene Detail
Summary
  • Symbol
    Trim21
  • Name
    tripartite motif-containing 21
  • Synonyms
    Ro52, Ssa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106657
    NCBI Gene: 20821
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:102207127-102214689 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.76 cM, cytoband F1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106657
 protein coding gene Chr7:102207127-102214693 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032614
 protein coding gene Chr7:105622920-105630452 (-)
A/J MGP_AJ_G0032590
 protein coding gene Chr7:102916472-102924004 (-)
AKR/J MGP_AKRJ_G0032526
 protein coding gene Chr7:105381482-105389014 (-)
BALB/cJ MGP_BALBcJ_G0032601
 protein coding gene Chr7:102616212-102623744 (-)
C3H/HeJ MGP_C3HHeJ_G0032315
 protein coding gene Chr7:105777316-105784848 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033098
 protein coding gene Chr7:109587058-109596286 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030092
 protein coding gene Chr7:105263249-105270842 (-)
CAST/EiJ MGP_CASTEiJ_G0031641
 protein coding gene Chr7:97330561-97338116 (-)
CBA/J MGP_CBAJ_G0032281
 protein coding gene Chr7:113425880-113433412 (-)
DBA/2J MGP_DBA2J_G0032433
 protein coding gene Chr7:101255152-101262684 (-)
FVB/NJ MGP_FVBNJ_G0032389
 protein coding gene Chr7:101021291-101028823 (-)
LP/J MGP_LPJ_G0032522
 protein coding gene Chr7:106933722-106941254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032423
 protein coding gene Chr7:114673450-114681001 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033120
 protein coding gene Chr7:104662095-104669625 (-)
PWK/PhJ MGP_PWKPhJ_G0031359
 protein coding gene Chr7:94361842-94369399 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031200
 protein coding gene Chr7:91944130-91952053 (-)
WSB/EiJ MGP_WSBEiJ_G0031758
 protein coding gene Chr7:105341421-105348951 (-)



Homology
more
  • Human Ortholog
    TRIM21, tripartite motif containing 21
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM21, tripartite motif containing 21
  • Synonyms
    RNF81, RO52, Ro/SSA, SSA, SSA1
  • Links
    NCBI Gene ID: 6737
    neXtProt AC: NX_P19474
    UniProt: P19474

  • Chr Location
    11p15.4; chr11:4384897-4393702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    4 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display reduced survival and abnormal immune responses. Mice homozygous for a second null allele display increased salivation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    78
  • cDNA Data
    42
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20821 NCBI Gene Model | MGI Sequence Detail 7563 C57BL/6J ±  kb
    transcript NM_009277 RefSeq | MGI Sequence Detail 2790 ZRU/MplStud  
    polypeptide Q62191 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35115
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 39
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:349718 Guo YY, et al., Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21. Cell Rep. 2024 Apr 23;43(4):114095
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory