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Ly75 Gene Detail
Summary
  • Symbol
    Ly75
  • Name
    lymphocyte antigen 75
  • Synonyms
    CD205, DEC-205
  • Feature Type
    protein coding gene
  • IDs
    MGI:106662
    NCBI Gene: 17076
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:60122447-60213617 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 34.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2560 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106662
 protein coding gene Chr2:60122447-60213647 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025761
 protein coding gene Chr2:59876896-59974181 (-)
A/J MGP_AJ_G0025737
 protein coding gene Chr2:57569057-57663289 (-)
AKR/J MGP_AKRJ_G0025707
 protein coding gene Chr2:59145789-59237849 (-)
BALB/cJ MGP_BALBcJ_G0025732
 protein coding gene Chr2:57671869-57779662 (-)
C3H/HeJ MGP_C3HHeJ_G0025493
 protein coding gene Chr2:59253878-59344846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026179
 protein coding gene Chr2:61638617-61735869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023583
 protein coding gene Chr2:55151050-55239178 (-)
CAST/EiJ MGP_CASTEiJ_G0024957
 protein coding gene Chr2:59294960-59389578 (-)
CBA/J MGP_CBAJ_G0025473
 protein coding gene Chr2:63987130-64086057 (-)
DBA/2J MGP_DBA2J_G0025604
 protein coding gene Chr2:57170932-57262709 (-)
FVB/NJ MGP_FVBNJ_G0025566
 protein coding gene Chr2:56719840-56810548 (-)
LP/J MGP_LPJ_G0025692
 protein coding gene Chr2:59726528-59819695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025597
 protein coding gene Chr2:65601676-65697750 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026236
 protein coding gene Chr2:59183540-59283795 (-)
PWK/PhJ MGP_PWKPhJ_G0024698
 protein coding gene Chr2:57025728-57120986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024505
 protein coding gene Chr2:59247405-59344919 (-)
WSB/EiJ MGP_WSBEiJ_G0025025
 protein coding gene Chr2:59472721-59567310 (-)



Homology
more
  • Human Ortholog
    LY75, lymphocyte antigen 75
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY75, lymphocyte antigen 75
  • Synonyms
    CD205, CLEC13B, DEC-205, GP200-MR6, LY-75
  • Links
    NCBI Gene ID: 4065
    neXtProt AC: NX_O60449
    UniProt: O60449

  • Chr Location
    2q24.2; chr2:159803355-159904756 (-)  GRCh38
  • Human Ortholog
    LY75-CD302, LY75-CD302 readthrough
  • Synonyms
    CD205, CLEC13B, DEC-205, gp200-MR6, Ly-75, LY75
  • Links
    NCBI Gene ID: 100526664
    neXtProt AC: NX_O60449

  • Chr Location
    2q24.2; chr2:159768628-159904756 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormalities in CD8-positive T cell morphology and cytotoxic T cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    6
  • cDNA Data
    22
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17076 NCBI Gene Model | MGI Sequence Detail 91171 C57BL/6J ±  kb
transcript NM_013825 RefSeq | MGI Sequence Detail 6871 C57BL/6  
polypeptide Q60767 UniProt | EBI | MGI Sequence Detail 1723 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35120
References
more
  • Summaries
    All 75
    Developmental Gene Expression 13
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:25283 Jiang W, et al., The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature. 1995 May 11;375(6527):151-5
  • Latest
    J:340979 Chen ST, et al., B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection. Immunity. 2023 Mar 14;56(3):547-561.e7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory