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Ptpn22 Gene Detail
Summary
  • Symbol
    Ptpn22
  • Name
    protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
  • Synonyms
    70zpep, Ptpn8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107170
    NCBI Gene: 19260
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:103767111-103819563 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.52 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    513 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107170
 protein coding gene Chr3:103763891-103819568 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027702
 protein coding gene Chr3:105152819-105211768 (+)
A/J MGP_AJ_G0027662
 protein coding gene Chr3:101807334-101861794 (+)
AKR/J MGP_AKRJ_G0027627
 protein coding gene Chr3:104286993-104343960 (+)
BALB/cJ MGP_BALBcJ_G0027674
 protein coding gene Chr3:101575135-101628768 (+)
C3H/HeJ MGP_C3HHeJ_G0027404
 protein coding gene Chr3:104658139-104714946 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028118
 protein coding gene Chr3:109047025-109104060 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025458
 protein coding gene Chr3:97928666-97983823 (+)
CAST/EiJ MGP_CASTEiJ_G0026860
 protein coding gene Chr3:103773676-103831284 (+)
CBA/J MGP_CBAJ_G0027379
 protein coding gene Chr3:112790902-112843640 (+)
DBA/2J MGP_DBA2J_G0027521
 protein coding gene Chr3:101049624-101105110 (+)
FVB/NJ MGP_FVBNJ_G0027489
 protein coding gene Chr3:98977376-99030507 (+)
LP/J MGP_LPJ_G0027628
 protein coding gene Chr3:106497073-106554008 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027519
 protein coding gene Chr3:118898386-118967688 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028173
 protein coding gene Chr3:103845156-103900828 (+)
PWK/PhJ MGP_PWKPhJ_G0026586
 protein coding gene Chr3:100822899-100880873 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026407
 protein coding gene Chr3:101912717-101967812 (+)
WSB/EiJ MGP_WSBEiJ_G0026940
 protein coding gene Chr3:104396400-104457831 (+)



Homology
more
  • Human Ortholog
    PTPN22, protein tyrosine phosphatase non-receptor type 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN22, protein tyrosine phosphatase non-receptor type 22
  • Synonyms
    LYP, LYP1, LYP2, PEP, PTPN22.5, PTPN22.6, PTPN8
  • Links
    NCBI Gene ID: 26191
    neXtProt AC: NX_Q9Y2R2
    UniProt: Q9Y2R2

  • Chr Location
    1p13.2; chr1:113813811-113871759 (-)  GRCh38
Human Diseases
more
  • Diseases
    28 with human PTPN22 associations

Human Disease Mouse Models
      
IDs
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 View 1 model
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 5 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    5 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display antigen dependent increases in T cell proliferation and cytokine production, enlarged spleens and lymph nodes, increased spontaneous germinal center formation, increased B cell numbers, and increased serum IgG and IgE levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    90
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    3
  • cDNA Data
    50
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027843 Ensembl Gene Model | MGI Sequence Detail 52453 C57BL/6J ±  kb
    transcript ENSMUST00000029433 Ensembl | MGI Sequence Detail 2743 Not Applicable  
    polypeptide ENSMUSP00000029433 Ensembl | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013457 tyrosine-protein phosphatase non-receptor type 22
      (term hierarchy)
    • PDB
      1JEG
    • EC
      3.1.3.48
    • InterPro Domains
      IPR016276 Non-receptor tyrosine-protein phosphatase 22
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR047170 Tyrosine-protein phosphatase non-receptor type 12/18/22
      IPR047253 Tyrosine-protein phosphatase non-receptor type 22, catalytic domain
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35631
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 18
      Phenotypes 45
    • Earliest
      J:32702 Matthews RJ, et al., Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol. 1992 May;12(5):2396-405
    • Latest
      J:353920 Liu S, et al., NADPH oxidase exerts a B cell-intrinsic contribution to lupus risk by modulating endosomal TLR signals. J Exp Med. 2024 Apr 1;221(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory