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Serpinf2 Gene Detail
Summary
  • Symbol
    Serpinf2
  • Name
    serine (or cysteine) peptidase inhibitor, clade F, member 2
  • Synonyms
    alpha 2 antiplasmin, Pli
  • Feature Type
    protein coding gene
  • IDs
    MGI:107173
    NCBI Gene: 18816
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75322562-75330327 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    247 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107173
 protein coding gene Chr11:75322558-75330417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018711
 protein coding gene Chr11:76176560-76185191 (-)
A/J MGP_AJ_G0018677
 protein coding gene Chr11:73345290-73353635 (-)
AKR/J MGP_AKRJ_G0018647
 protein coding gene Chr11:75563413-75575196 (-)
BALB/cJ MGP_BALBcJ_G0018651
 protein coding gene Chr11:73716069-73725168 (-)
C3H/HeJ MGP_C3HHeJ_G0018464
 protein coding gene Chr11:75577329-75590834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019102
 protein coding gene Chr11:78563225-78571136 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016737
 protein coding gene Chr11:70354506-70362156 (-)
CAST/EiJ MGP_CASTEiJ_G0018018
 protein coding gene Chr11:75971356-75980624 (-)
CBA/J MGP_CBAJ_G0018434
 protein coding gene Chr11:82003149-82017943 (-)
DBA/2J MGP_DBA2J_G0018543
 protein coding gene Chr11:72950605-72958416 (-)
FVB/NJ MGP_FVBNJ_G0018533
 protein coding gene Chr11:72509622-72518089 (-)
LP/J MGP_LPJ_G0018614
 protein coding gene Chr11:76761038-76772287 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018559
 protein coding gene Chr11:82576763-82587911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019142
 protein coding gene Chr11:75772494-75780862 (-)
PWK/PhJ MGP_PWKPhJ_G0017789
 protein coding gene Chr11:73644887-73653346 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017580
 protein coding gene Chr11:75327529-75335372 (-)
WSB/EiJ MGP_WSBEiJ_G0018071
 protein coding gene Chr11:75579612-75587373 (-)



Homology
more
  • Human Ortholog
    SERPINF2, serpin family F member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINF2, serpin family F member 2
  • Synonyms
    A2AP, AAP, alpha2AP, ALPHA-2-PI, API, PLI
  • Links
    NCBI Gene ID: 5345
    neXtProt AC: NX_P08697
    UniProt: P08697

  • Chr Location
    17p13.3; chr17:1742836-1755265 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Serpinf2 mouse models; 2 with human SERPINF2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have an essentially normal phenotype. Spontaneous lysis of blood clots occurs more readily but bleeding times are unaffected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    14
  • cDNA Data
    154
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18816 NCBI Gene Model | MGI Sequence Detail 7766 C57BL/6J ±  kb
transcript NM_008878 RefSeq | MGI Sequence Detail 2199 C57BL/6  
polypeptide Q61247 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 164
    Genomic 6
    cDNA 154
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35634, MGI:2144263
References
more
  • Summaries
    All 63
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 10
    Phenotypes 29
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:288446 Christians A, et al., Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory