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Bcl6 Gene Detail
Summary
  • Symbol
    Bcl6
  • Name
    B cell leukemia/lymphoma 6
  • Synonyms
    Bcl5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107187
    NCBI Gene: 12053
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23783802-23807602 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 15.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    484 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107187
 protein coding gene Chr16:23780058-23807602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022688
 protein coding gene Chr16:21570539-21594975 (-)
A/J MGP_AJ_G0022650
 protein coding gene Chr16:20551755-20575819 (-)
AKR/J MGP_AKRJ_G0022624
 protein coding gene Chr16:21418129-21441797 (-)
BALB/cJ MGP_BALBcJ_G0022655
 protein coding gene Chr16:20749511-20773346 (-)
C3H/HeJ MGP_C3HHeJ_G0022419
 protein coding gene Chr16:21539807-21563794 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023104
 protein coding gene Chr16:22105576-22130646 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020622
 protein coding gene Chr16:21178543-21202239 (-)
CAST/EiJ MGP_CASTEiJ_G0021948
 protein coding gene Chr16:21540292-21569763 (-)
CBA/J MGP_CBAJ_G0022390
 protein coding gene Chr16:23022799-23051865 (-)
DBA/2J MGP_DBA2J_G0022522
 protein coding gene Chr16:20507732-20531357 (-)
FVB/NJ MGP_FVBNJ_G0022498
 protein coding gene Chr16:20507085-20532309 (-)
LP/J MGP_LPJ_G0022590
 protein coding gene Chr16:21372959-21398450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022517
 protein coding gene Chr16:22491523-22515246 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023116
 protein coding gene Chr16:21374124-21400344 (-)
PWK/PhJ MGP_PWKPhJ_G0021687
 protein coding gene Chr16:20785748-20809999 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021518
 protein coding gene Chr16:21108619-21134832 (-)
WSB/EiJ MGP_WSBEiJ_G0021992
 protein coding gene Chr16:21330260-21356097 (-)



Homology
more
  • Human Ortholog
    BCL6, BCL6 transcription repressor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL6, BCL6 transcription repressor
  • Synonyms
    BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
  • Links
    NCBI Gene ID: 604
    neXtProt AC: NX_P41182
    UniProt: P41182

  • Chr Location
    3q27.3; chr3:187721377-187745725 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BCL6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 8 alleles in 13 genetic backgrounds
    20 phenotypes from multigenic genotypes
    209 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants develop myocarditis and pulmonary vasculitis, show impaired germinal center formation in the spleen, and display T helper 2 cell hyperimmune responsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    113
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    140
  • cDNA Data
    54
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022508 Ensembl Gene Model | MGI Sequence Detail 23801 C57BL/6J ±  kb
    transcript ENSMUST00000023151 Ensembl | MGI Sequence Detail 3525 Not Applicable  
    polypeptide ENSMUSP00000023151 Ensembl | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 55
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35648, MGI:1277984
    References
    more
    • Summaries
      All 340
      Developmental Gene Expression 29
      Gene Ontology 35
      Phenotypes 209
    • Earliest
      J:29534 Fukuda T, et al., The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene. 1995 Oct 19;11(8):1657-63
    • Latest
      J:354962 Akama-Garren EH, et al., T cell help shapes B cell tolerance. Sci Immunol. 2024 Feb 16;9(92):eadj7029
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory