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Ctse Gene Detail
Summary
  • Symbol
    Ctse
  • Name
    cathepsin E
  • Synonyms
    A430072O03Rik, C920004C08Rik, CatE, CE
  • Feature Type
    protein coding gene
  • IDs
    MGI:107361
    NCBI Gene: 13034
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131566052-131603245 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.14 cM, cytoband F
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1031 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107361
 protein coding gene Chr1:131566044-131603245 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016456
 protein coding gene Chr1:135080563-135108783 (+)
A/J MGP_AJ_G0016439
 protein coding gene Chr1:130083959-130117394 (+)
AKR/J MGP_AKRJ_G0016404
 protein coding gene Chr1:133910583-133938583 (+)
BALB/cJ MGP_BALBcJ_G0016399
 protein coding gene Chr1:130411304-130440383 (+)
C3H/HeJ MGP_C3HHeJ_G0016225
 protein coding gene Chr1:134050587-134085433 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016860
 protein coding gene Chr1:140099241-140135235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014574
 protein coding gene Chr1:123218753-123247643 (+)
CAST/EiJ MGP_CASTEiJ_G0015805
 protein coding gene Chr1:133047526-133077336 (+)
CBA/J MGP_CBAJ_G0016197
 protein coding gene Chr1:144894495-144922462 (+)
DBA/2J MGP_DBA2J_G0016304
 protein coding gene Chr1:129053441-129081312 (+)
FVB/NJ MGP_FVBNJ_G0016303
 protein coding gene Chr1:127679359-127707137 (+)
LP/J MGP_LPJ_G0016375
 protein coding gene Chr1:136388208-136419961 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016328
 protein coding gene Chr1:150656731-150701316 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016896
 protein coding gene Chr1:133661932-133690498 (+)
PWK/PhJ MGP_PWKPhJ_G0015591
 protein coding gene Chr1:128009095-128038186 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015378
 protein coding gene Chr1:132613049-132641342 (+)
WSB/EiJ MGP_WSBEiJ_G0015867
 protein coding gene Chr1:133653203-133681759 (+)



Homology
more
  • Human Ortholog
    CTSE, cathepsin E
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSE, cathepsin E
  • Synonyms
    CATE
  • Links
    NCBI Gene ID: 1510
    neXtProt AC: NX_P14091
    UniProt: P14091

  • Chr Location
    1q32.1; chr1:206008535-206023909 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ctse mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    27
  • cDNA Data
    45
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13034 NCBI Gene Model | MGI Sequence Detail 37194 C57BL/6J ±  kb
    transcript NM_007799 RefSeq | MGI Sequence Detail 2120 ZRU/MplStud  
    polypeptide P70269 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 46
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35827, MGI:2441798, MGI:2441925
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory