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Msi1 Gene Detail
Summary
  • Symbol
    Msi1
  • Name
    musashi RNA-binding protein 1
  • Synonyms
    m-Msi-1, Msi1, Msi1h, Musahi1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107376
    NCBI Gene: 17690
  • Alliance
    gene page
  • Transcription Start Sites
    40 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115567734-115593757 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.09 cM, cytoband E3-F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    687 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107376
 protein coding gene Chr5:115567658-115593757 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029969
 protein coding gene Chr5:118309003-118338306 (+)
A/J MGP_AJ_G0029933
 protein coding gene Chr5:113598079-113624072 (+)
AKR/J MGP_AKRJ_G0029872
 protein coding gene Chr5:117243889-117269946 (+)
BALB/cJ MGP_BALBcJ_G0029944
 protein coding gene Chr5:114993239-115020360 (+)
C3H/HeJ MGP_C3HHeJ_G0029664
 protein coding gene Chr5:117749215-117778013 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030399
 protein coding gene Chr5:122864622-122893624 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027626
 protein coding gene Chr5:108372137-108397451 (+)
CAST/EiJ MGP_CASTEiJ_G0029073
 protein coding gene Chr5:116681390-116712955 (+)
CBA/J MGP_CBAJ_G0029632
 protein coding gene Chr5:127585629-127614134 (+)
DBA/2J MGP_DBA2J_G0029782
 protein coding gene Chr5:113672969-113699656 (+)
FVB/NJ MGP_FVBNJ_G0029738
 protein coding gene Chr5:112503622-112529669 (+)
LP/J MGP_LPJ_G0029870
 protein coding gene Chr5:118863517-118893409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029769
 protein coding gene Chr5:131890376-131921216 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030440
 protein coding gene Chr5:116710937-116740084 (+)
PWK/PhJ MGP_PWKPhJ_G0028786
 protein coding gene Chr5:112331924-112358280 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028624
 protein coding gene Chr5:114258630-114290748 (+)
WSB/EiJ MGP_WSBEiJ_G0029148
 protein coding gene Chr5:117303371-117332994 (+)



Homology
more
  • Human Ortholog
    MSI1, musashi RNA binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSI1, musashi RNA binding protein 1
  • Links
    NCBI Gene ID: 4440
    neXtProt AC: NX_O43347
    UniProt: O43347

  • Chr Location
    12q24.31; chr12:120339662-120369164 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mice develop hydrocephalus associated with progressive ventricular dilation, a large domed cranium, thin cerebral cortices, callosal agenesis, aberrant proliferation and polyposis of ependymal cells, intracerebral bleeding, ataxia, dehydration and death at 1-2 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    112
  • cDNA Data
    8
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17690 NCBI Gene Model | MGI Sequence Detail 26024 C57BL/6J ±  kb
    transcript NM_001376963 RefSeq | MGI Sequence Detail 3204 C57BL/6  
    polypeptide Q61474 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 8
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35843
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 38
      Gene Ontology 8
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346611 Banik J, et al., The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs. Sci Rep. 2024 Mar 11;14(1):5918
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory