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Epha1 Gene Detail
Summary
  • Symbol
    Epha1
  • Name
    Eph receptor A1
  • Synonyms
    5730453L17Rik, Eph, Esk
  • Feature Type
    protein coding gene
  • IDs
    MGI:107381
    NCBI Gene: 13835
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:42335421-42350202 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 20.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107381
 protein coding gene Chr6:42335421-42350249 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030649
 protein coding gene Chr6:40875064-40890862 (-)
A/J MGP_AJ_G0030622
 protein coding gene Chr6:39088854-39103628 (-)
AKR/J MGP_AKRJ_G0030547
 protein coding gene Chr6:40351688-40366455 (-)
BALB/cJ MGP_BALBcJ_G0030632
 protein coding gene Chr6:39334283-39360238 (-)
C3H/HeJ MGP_C3HHeJ_G0030345
 protein coding gene Chr6:40386660-40403177 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031086
 protein coding gene Chr6:41898437-41913426 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028293
 protein coding gene Chr6:36970278-36985175 (-)
CAST/EiJ MGP_CASTEiJ_G0029749
 protein coding gene Chr6:40220788-40235560 (-)
CBA/J MGP_CBAJ_G0030321
 protein coding gene Chr6:43594688-43610639 (-)
DBA/2J MGP_DBA2J_G0030465
 protein coding gene Chr6:38938250-38953111 (-)
FVB/NJ MGP_FVBNJ_G0030421
 protein coding gene Chr6:38686508-38701255 (-)
LP/J MGP_LPJ_G0030553
 protein coding gene Chr6:40834940-40852037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030455
 protein coding gene Chr6:45870181-45886369 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031116
 protein coding gene Chr6:40325487-40341356 (-)
PWK/PhJ MGP_PWKPhJ_G0029461
 protein coding gene Chr6:38501194-38516174 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029297
 protein coding gene Chr6:39887447-39902232 (-)
WSB/EiJ MGP_WSBEiJ_G0029825
 protein coding gene Chr6:40315224-40330788 (-)



Homology
more
  • Human Ortholog
    EPHA1, EPH receptor A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA1, EPH receptor A1
  • Synonyms
    EPH, EPHT, EPHT1
  • Links
    NCBI Gene ID: 2041
    neXtProt AC: NX_P21709
    UniProt: P21709

  • Chr Location
    7q34-q35; chr7:143390289-143408856 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a null allele exhibit a kinked tail while 18% of mice exhibit vagina atresia with hydrometrocolops and infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    972
  • Tissues
    199
  • cDNA Data
    30
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029859 Ensembl Gene Model | MGI Sequence Detail 14782 C57BL/6J ±  kb
    transcript ENSMUST00000073387 Ensembl | MGI Sequence Detail 3273 Not Applicable  
    polypeptide ENSMUSP00000073099 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007120 ephrin type-A receptor 1
      (term hierarchy)
    • PDB
      1X5A
    • EC
      2.7.10.1
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR034251 Ephrin type-A receptor 1, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      Q60750 2 sites
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 31
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35848, MGI:1917831, MGI:2141544
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 25
      Gene Ontology 12
      Phenotypes 9
    • Earliest
      J:17222 Tuzi NL, et al., eph, the largest known family of putative growth factor receptors. Br J Cancer. 1994 Mar;69(3):417-21
    • Latest
      J:327333 Yang KY, et al., Ca(2+) homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling. Cell Death Dis. 2022 Aug 4;13(8):674
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory