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Ptprn2 Gene Detail
Summary
  • Symbol
    Ptprn2
  • Name
    protein tyrosine phosphatase receptor type N polypeptide 2
  • Synonyms
    4930425H11Rik, IA-2 beta, IA-2beta, phogrin, PTP-NP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107418
    NCBI Gene: 19276
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:116449340-117240469 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.65 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23053 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107418
 protein coding gene Chr12:116449316-117241787 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020183
 protein coding gene Chr12:119353462-120170299 (+)
A/J MGP_AJ_G0020139
 protein coding gene Chr12:114993921-115762486 (+)
AKR/J MGP_AKRJ_G0020114
 protein coding gene Chr12:118486392-119265367 (+)
BALB/cJ MGP_BALBcJ_G0020122
 protein coding gene Chr12:115427714-116182040 (+)
C3H/HeJ MGP_C3HHeJ_G0019926
 protein coding gene Chr12:118758006-119554073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020569
 protein coding gene Chr12:123131818-123944169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018181
 protein coding gene Chr12:111407661-112156439 (+)
CAST/EiJ MGP_CASTEiJ_G0019466
 protein coding gene Chr12:112599411-113402004 (+)
CBA/J MGP_CBAJ_G0019893
 protein coding gene Chr12:128009049-128837732 (+)
DBA/2J MGP_DBA2J_G0020010
 protein coding gene Chr12:114359487-115154694 (+)
FVB/NJ MGP_FVBNJ_G0019995
 protein coding gene Chr12:113054220-113832187 (+)
LP/J MGP_LPJ_G0020084
 protein coding gene Chr12:119394588-120211992 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020031
 protein coding gene Chr12:131320325-132133438 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020598
 protein coding gene Chr12:117650973-118443703 (+)
PWK/PhJ MGP_PWKPhJ_G0019228
 protein coding gene Chr12:109119889-109897919 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019033
 protein coding gene Chr12:110595341-111387236 (+)
WSB/EiJ MGP_WSBEiJ_G0019524
 protein coding gene Chr12:118606320-119397638 (+)



Homology
more
  • Human Ortholog
    PTPRN2, protein tyrosine phosphatase receptor type N2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRN2, protein tyrosine phosphatase receptor type N2
  • Synonyms
    IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2
  • Links
    NCBI Gene ID: 5799
    neXtProt AC: NX_Q92932
    UniProt: Q92932

  • Chr Location
    7q36.3; chr7:157539056-158587823 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ptprn2 mouse models; 2 with human PTPRN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired glucose tolerance but normal fasting and non-fasting blood glucose and insulin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    28
  • cDNA Data
    27
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056553 Ensembl Gene Model | MGI Sequence Detail 791130 C57BL/6J ±  kb
transcript ENSMUST00000070733 Ensembl | MGI Sequence Detail 3201 Not Applicable  
polypeptide ENSMUSP00000064046 Ensembl | MGI Sequence Detail 1001 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013475 receptor-type tyrosine-protein phosphatase N2
    (term hierarchy)
  • EC
    3.1.3.-, 3.1.3.48
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
    IPR038112 Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily
    IPR033522 Receptor-type tyrosine-protein phosphatase-like N/N2
    IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
    IPR000387 Tyrosine-specific protein phosphatases domain
  • GlyGen
    P80560 3 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 31
    Genomic 1
    cDNA 30

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35887, MGI:1921110
References
more
  • Summaries
    All 54
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:34182 Chiang MK, et al., PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Development. 1996 Jul;122(7):2239-50
  • Latest
    J:334795 Sokanovic SJ, et al., Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction. Sci Rep. 2023 Jan 7;13(1):355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory