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Il11ra1 Gene Detail
Summary
  • Symbol
    Il11ra1
  • Name
    interleukin 11 receptor subunit alpha 1
  • Synonyms
    Il-11ra, Il11ra, Il-11ra-alpha, NR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107426
    NCBI Gene: 16157
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41760443-41769473 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 21.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107426
 protein coding gene Chr4:41699989-41769474 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028173
 protein coding gene Chr4:39727080-39736648 (+)
A/J MGP_AJ_G0028131
 protein coding gene Chr4:38216649-38226472 (+)
AKR/J MGP_AKRJ_G0028094
 protein coding gene Chr4:39209087-39237390 (+)
BALB/cJ MGP_BALBcJ_G0028144
 protein coding gene Chr4:38559322-38569215 (+)
C3H/HeJ MGP_C3HHeJ_G0027866
 protein coding gene Chr4:39688142-39699000 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027327
 protein coding gene Chr4:39443568-39457674 (+)
CBA/J MGP_CBAJ_G0027844
 protein coding gene Chr4:42594937-42604247 (+)
DBA/2J MGP_DBA2J_G0027988
 protein coding gene Chr4:38144619-38153897 (+)
FVB/NJ MGP_FVBNJ_G0027955
 protein coding gene Chr4:37464966-37474244 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027987
 protein coding gene Chr4:45907347-45913931 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028643
 protein coding gene Chr4:39319770-39331034 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    IL11RA, interleukin 11 receptor subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL11RA, interleukin 11 receptor subunit alpha
  • Synonyms
    CRSDA
  • Links
    NCBI Gene ID: 3590
    neXtProt AC: NX_Q14626
    UniProt: Q14626

  • Chr Location
    9p13.3; chr9:34652162-34661902 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female homozygotes for targeted null mutations are infertile due to defective decidua formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1256
  • Tissues
    58
  • cDNA Data
    101
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16157 NCBI Gene Model | MGI Sequence Detail 9031 C57BL/6J ±  kb
    transcript NM_001172054 RefSeq | MGI Sequence Detail 1847 C57BL/6  
    polypeptide Q64385 UniProt | EBI | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 6
      cDNA 110
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35897, MGI:3034462
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 49
    • Earliest
      J:21233 Hilton DJ, et al., Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 1994 Oct 17;13(20):4765-75
    • Latest
      J:353582 Huber A, et al., Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines. Cell Rep. 2024 Aug 27;43(8):114616
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory