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Fpr1 Gene Detail
Summary
  • Symbol
    Fpr1
  • Name
    formyl peptide receptor 1
  • Synonyms
    fMLF-R, FPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:107443
    NCBI Gene: 14293
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:18096733-18104201 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 10.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107443
 protein coding gene Chr17:18096733-18104202 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023186
 protein coding gene Chr17:15882872-15890348 (-)
A/J MGP_AJ_G0023151
 protein coding gene Chr17:15528112-15535557 (-)
AKR/J MGP_AKRJ_G0023121
 protein coding gene Chr17:15603569-15611007 (-)
BALB/cJ MGP_BALBcJ_G0023151
 protein coding gene Chr17:15473443-15480972 (-)
C3H/HeJ MGP_C3HHeJ_G0022911
 protein coding gene Chr17:15829870-15840102 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023594
 protein coding gene Chr17:16671339-16679037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021106
 protein coding gene Chr17:13375683-13383193 (-)
CAST/EiJ MGP_CASTEiJ_G0022430
 protein coding gene Chr17:15638733-15646167 (-)
CBA/J MGP_CBAJ_G0022888
 protein coding gene Chr17:17240709-17248384 (-)
DBA/2J MGP_DBA2J_G0023021
 protein coding gene Chr17:15242286-15249753 (-)
FVB/NJ MGP_FVBNJ_G0022989
 protein coding gene Chr17:15055682-15063631 (-)
LP/J MGP_LPJ_G0023095
 protein coding gene Chr17:15876623-15884073 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023010
 protein coding gene Chr17:16831222-16838634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023631
 protein coding gene Chr17:15795074-15802543 (-)
PWK/PhJ MGP_PWKPhJ_G0022179
 protein coding gene Chr17:14875525-14882987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022007
 protein coding gene Chr17:14884761-14892848 (-)
WSB/EiJ MGP_WSBEiJ_G0022489
 protein coding gene Chr17:16079264-16086737 (-)



Homology
more
  • Human Ortholog
    FPR1, formyl peptide receptor 1
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FPR1, formyl peptide receptor 1
  • Synonyms
    FMLP, FPR
  • Links
    NCBI Gene ID: 2357
    neXtProt AC: NX_P21462
    UniProt: P21462

  • Chr Location
    19q13.41; chr19:51745172-51804115 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mice are viable and developmentally normal but show increased susceptibility to L. monocytogenes challenge, as shown by increased mortality and bacterial burden in liver/spleen early post-infection. Mutant neutrophils fail to respond to fMLF either in calcium flux or chemotaxis assays.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14293 NCBI Gene Model | MGI Sequence Detail 7469 C57BL/6J ±  kb
transcript NM_013521 RefSeq | MGI Sequence Detail 1332 ZRU/MplStud  
polypeptide P33766 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 7
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35914
References
more
  • Summaries
    All 80
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 42
  • Earliest
    J:43394 Gao JL, et al., Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains. J Biol Chem. 1993 Dec 5;268(34):25395-401
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory