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Nxph1 Gene Detail
Summary
  • Symbol
    Nxph1
  • Name
    neurexophilin 1
  • Synonyms
    C130005L03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107492
    NCBI Gene: 18231
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:8948431-9249032 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 4.38 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7716 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107492
 protein coding gene Chr6:8948154-9259863 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030453
 protein coding gene Chr6:5890945-6198091 (+)
A/J MGP_AJ_G0030426
 protein coding gene Chr6:5677688-5984018 (+)
AKR/J MGP_AKRJ_G0030353
 protein coding gene Chr6:5889338-6207909 (+)
BALB/cJ MGP_BALBcJ_G0030435
 protein coding gene Chr6:5658539-5969734 (+)
C3H/HeJ MGP_C3HHeJ_G0030149
 protein coding gene Chr6:5782747-6090344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030890
 protein coding gene Chr6:6066402-6389983 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028101
 protein coding gene Chr6:5170000-5466324 (+)
CAST/EiJ MGP_CASTEiJ_G0029550
 protein coding gene Chr6:5768780-6083850 (+)
CBA/J MGP_CBAJ_G0030127
 protein coding gene Chr6:6211798-6514501 (+)
DBA/2J MGP_DBA2J_G0030271
 protein coding gene Chr6:5614983-5911169 (+)
FVB/NJ MGP_FVBNJ_G0030225
 protein coding gene Chr6:5578877-5873446 (+)
LP/J MGP_LPJ_G0030358
 protein coding gene Chr6:5855578-6177776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030261
 protein coding gene Chr6:6317857-6673933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030920
 protein coding gene Chr6:5761676-6077078 (+)
PWK/PhJ MGP_PWKPhJ_G0029265
 protein coding gene Chr6:5502585-5805271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029101
 protein coding gene Chr6:5817787-6126647 (+)
WSB/EiJ MGP_WSBEiJ_G0029627
 protein coding gene Chr6:5762660-6074068 (+)



Homology
more
  • Human Ortholog
    NXPH1, neurexophilin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXPH1, neurexophilin 1
  • Synonyms
    Nbla00697, NPH1
  • Links
    NCBI Gene ID: 30010
    neXtProt AC: NX_P58417
    UniProt: P58417

  • Chr Location
    7p21.3; chr7:8433609-8752961 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation show no obvious morbidity, premature mortality, or anatomical defects. However, males exhibit sterility and testis abnormalities probably because homologous recombination results in co-insertion of the 5' part of the HSV-TK cassette into the targeted locus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    22
  • cDNA Data
    14
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046178 Ensembl Gene Model | MGI Sequence Detail 300602 C57BL/6J ±  kb
    transcript ENSMUST00000160300 Ensembl | MGI Sequence Detail 2815 Not Applicable  
    polypeptide ENSMUSP00000125274 Ensembl | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36060, MGI:2444857
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 14
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:34033 Petrenko AG, et al., Structure and evolution of neurexophilin. J Neurosci. 1996 Jul 15;16(14):4360-9
    • Latest
      J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory