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Sema4a Gene Detail
Summary
  • Symbol
    Sema4a
  • Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
  • Synonyms
    Semab, SemB, SemB
  • Feature Type
    protein coding gene
  • IDs
    MGI:107560
    NCBI Gene: 20351
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88343266-88368489 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    639 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107560
 protein coding gene Chr3:88343266-88368500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027397
 protein coding gene Chr3:88594494-88617634 (-)
A/J MGP_AJ_G0027361
 protein coding gene Chr3:85610401-85633555 (-)
AKR/J MGP_AKRJ_G0027325
 protein coding gene Chr3:87721389-87746292 (-)
BALB/cJ MGP_BALBcJ_G0027370
 protein coding gene Chr3:85694807-85717939 (-)
C3H/HeJ MGP_C3HHeJ_G0027112
 protein coding gene Chr3:87979326-88002484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027816
 protein coding gene Chr3:91896509-91919651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025168
 protein coding gene Chr3:81208606-81234347 (-)
CAST/EiJ MGP_CASTEiJ_G0026558
 protein coding gene Chr3:88211173-88239135 (-)
CBA/J MGP_CBAJ_G0027086
 protein coding gene Chr3:95043599-95066576 (-)
DBA/2J MGP_DBA2J_G0027224
 protein coding gene Chr3:85091556-85114583 (-)
FVB/NJ MGP_FVBNJ_G0027192
 protein coding gene Chr3:83359848-83382883 (-)
LP/J MGP_LPJ_G0027333
 protein coding gene Chr3:89608345-89631598 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027212
 protein coding gene Chr3:101274757-101297899 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027875
 protein coding gene Chr3:87466709-87489849 (-)
PWK/PhJ MGP_PWKPhJ_G0026292
 protein coding gene Chr3:84867931-84893727 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026111
 protein coding gene Chr3:86642109-86667198 (-)
WSB/EiJ MGP_WSBEiJ_G0026640
 protein coding gene Chr3:87814022-87843708 (-)



Homology
more
  • Human Ortholog
    SEMA4A, semaphorin 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA4A, semaphorin 4A
  • Synonyms
    CORD10, RP35, SEMAB, SEMB
  • Links
    NCBI Gene ID: 64218
    neXtProt AC: NX_Q9H3S1
    UniProt: Q9H3S1

  • Chr Location
    1q22; chr1:156147366-156177752 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SEMA4A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 7 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show no obvious brain defects but exhibit impaired T cell priming and defective Th1 responses. Homozygotes for a gene trap allele show severe retinal degeneration with reduced retinal vessels, depigmentation and dysfunction of both rod and cone photoreceptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    70
  • cDNA Data
    83
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028064 Ensembl Gene Model | MGI Sequence Detail 25224 C57BL/6J ±  kb
    transcript ENSMUST00000169222 Ensembl | MGI Sequence Detail 3084 Not Applicable  
    polypeptide ENSMUSP00000128887 Ensembl | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 84
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36131, MGI:2139635
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 8
      Phenotypes 31
    • Earliest
      J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
    • Latest
      J:344401 Bhat GP, et al., Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve. Neuron. 2024 Jan 17;112(2):209-229.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory