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Cd1d1 Gene Detail
Summary
  • Symbol
    Cd1d1
  • Name
    CD1d1 antigen
  • Synonyms
    CD1.1, Cd1a, Cd1d, Ly-38
  • Feature Type
    protein coding gene
  • IDs
    MGI:107674
    NCBI Gene: 12479
  • Member of
    Cd1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:86903141-86906748 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.91 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107674
 protein coding gene Chr3:86903141-86919665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027358
 protein coding gene Chr3:87072177-87074772 (-)
A/J MGP_AJ_G0027322
 protein coding gene Chr3:84103150-84105529 (-)
AKR/J MGP_AKRJ_G0027288
 protein coding gene Chr3:86150515-86154805 (-)
BALB/cJ MGP_BALBcJ_G0027331
 protein coding gene Chr3:84207353-84210205 (-)
C3H/HeJ MGP_C3HHeJ_G0027074
 protein coding gene Chr3:86425503-86427838 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027776
 protein coding gene Chr3:90286473-90292851 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025130
 protein coding gene Chr3:79780642-79783372 (-)
CAST/EiJ MGP_CASTEiJ_G0026521
 protein coding gene Chr3:86656429-86658453 (-)
CBA/J MGP_CBAJ_G0027049
 protein coding gene Chr3:93328094-93330860 (-)
DBA/2J MGP_DBA2J_G0027185
 protein coding gene Chr3:83614275-83617446 (-)
FVB/NJ MGP_FVBNJ_G0027154
 protein coding gene Chr3:81930160-81932405 (-)
LP/J MGP_LPJ_G0027293
 protein coding gene Chr3:88014025-88016390 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027173
 protein coding gene Chr3:99618642-99621296 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027835
 protein coding gene Chr3:85917017-85921461 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026071
 protein coding gene Chr3:85097250-85114504 (-)
WSB/EiJ MGP_WSBEiJ_G0026599
 protein coding gene Chr3:86300626-86305023 (-)



Homology
more
  • Human Ortholog
    CD1D, CD1d molecule
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD1D, CD1d molecule
  • Synonyms
    CD1A, R3, R3G1
  • Links
    NCBI Gene ID: 912
    neXtProt AC: NX_P15813
    UniProt: P15813

  • Chr Location
    1q23.1; chr1:158178030-158186427 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD1D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 7 alleles in 14 genetic backgrounds
    9 phenotypes from multigenic genotypes
    469 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations lack natural killer T cells, and mutant splenocytes fail to produce interleukin 4 (IL4).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    11
  • cDNA Data
    48
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028076 Ensembl Gene Model | MGI Sequence Detail 3608 C57BL/6J ±  kb
    transcript ENSMUST00000029717 Ensembl | MGI Sequence Detail 1946 Not Applicable  
    polypeptide ENSMUSP00000029717 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 5
      cDNA 52
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11979, MGD-MRK-1834, MGD-MRK-1836, MGD-MRK-36249, MGI:2139791
    References
    more
    • Summaries
      All 582
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 15
      Phenotypes 469
    • Earliest
      J:17169 McMichael AJ, et al., A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol. 1979 Mar;9(3):205-10
    • Latest
      J:355000 Loh L, et al., Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models. Cell Rep. 2024 Sep 24;43(9):114705
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory