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Ndufa4 Gene Detail
Summary
  • Symbol
    Ndufa4
  • Name
    Ndufa4, mitochondrial complex associated
  • Synonyms
    MLRQ
  • Feature Type
    protein coding gene
  • IDs
    MGI:107686
    NCBI Gene: 17992
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:11900371-11907449 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 5.01 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107686
 protein coding gene Chr6:11900291-11907496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030454
 protein coding gene Chr6:8906357-8913422 (-)
A/J MGP_AJ_G0030427
 protein coding gene Chr6:8572813-8579878 (-)
AKR/J MGP_AKRJ_G0030354
 protein coding gene Chr6:8887550-8894606 (-)
BALB/cJ MGP_BALBcJ_G0030436
 protein coding gene Chr6:8592898-8599963 (-)
C3H/HeJ MGP_C3HHeJ_G0030150
 protein coding gene Chr6:8804873-8811938 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030891
 protein coding gene Chr6:9306422-9313478 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028102
 protein coding gene Chr6:7917006-7924174 (-)
CAST/EiJ MGP_CASTEiJ_G0029552
 protein coding gene Chr6:8666196-8676084 (-)
CBA/J MGP_CBAJ_G0030128
 protein coding gene Chr6:9430909-9438775 (-)
DBA/2J MGP_DBA2J_G0030272
 protein coding gene Chr6:8522424-8529489 (-)
FVB/NJ MGP_FVBNJ_G0030226
 protein coding gene Chr6:8437392-8444457 (-)
LP/J MGP_LPJ_G0030359
 protein coding gene Chr6:8869638-8876703 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030262
 protein coding gene Chr6:10000084-10007716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030921
 protein coding gene Chr6:8749572-8756637 (-)
PWK/PhJ MGP_PWKPhJ_G0029266
 protein coding gene Chr6:8283232-8293557 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029102
 protein coding gene Chr6:8718913-8725569 (-)
WSB/EiJ MGP_WSBEiJ_G0029628
 protein coding gene Chr6:8716149-8723206 (-)



Homology
more
  • Human Ortholog
    NDUFA4, NDUFA4 mitochondrial complex associated
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDUFA4, NDUFA4 mitochondrial complex associated
  • Synonyms
    CI-9k, CI-MLRQ, COXFA4, MC4DN21, MISTR1, MLRQ, MRCAF1
  • Links
    NCBI Gene ID: 4697
    neXtProt AC: NX_O00483
    UniProt: O00483

  • Chr Location
    7p21.3; chr7:10931943-10940153 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NDUFA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1100
  • Tissues
    164
  • cDNA Data
    231
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17992 NCBI Gene Model | MGI Sequence Detail 7079 C57BL/6J ±  kb
transcript NM_010886 RefSeq | MGI Sequence Detail 513 C57BL/6  
polypeptide Q62425 UniProt | EBI | MGI Sequence Detail 82 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 232
    cDNA 231
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-36261
References
more
  • Summaries
    All 43
    Developmental Gene Expression 8
    Gene Ontology 12
    Phenotypes 3
  • Earliest
    J:26935 Chen S, et al., Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes. Mol Pharmacol. 1995 May;47(5):934-9
  • Latest
    J:329220 Chen Y, et al., Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory