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Abcg1 Gene Detail
Summary
  • Symbol
    Abcg1
  • Name
    ATP binding cassette subfamily G member 1
  • Synonyms
    Abc8, White
  • Feature Type
    protein coding gene
  • IDs
    MGI:107704
    NCBI Gene: 11307
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31276668-31336958 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.80 cM, cytoband A2-B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2073 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107704
 protein coding gene Chr17:31276649-31336962 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023480
 protein coding gene Chr17:30785446-30846598 (+)
A/J MGP_AJ_G0023438
 protein coding gene Chr17:29786272-29844876 (+)
AKR/J MGP_AKRJ_G0023403
 protein coding gene Chr17:30032488-30090481 (+)
BALB/cJ MGP_BALBcJ_G0023443
 protein coding gene Chr17:29893652-29952718 (+)
C3H/HeJ MGP_C3HHeJ_G0023204
 protein coding gene Chr17:30414918-30475860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023885
 protein coding gene Chr17:31860999-31920457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021359
 protein coding gene Chr17:26927030-26985028 (+)
CAST/EiJ MGP_CASTEiJ_G0022705
 protein coding gene Chr17:30438071-30498526 (+)
CBA/J MGP_CBAJ_G0023179
 protein coding gene Chr17:33273174-33337266 (+)
DBA/2J MGP_DBA2J_G0023309
 protein coding gene Chr17:29203820-29262964 (+)
FVB/NJ MGP_FVBNJ_G0023279
 protein coding gene Chr17:28985834-29045394 (+)
LP/J MGP_LPJ_G0023387
 protein coding gene Chr17:31008892-31071800 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023297
 protein coding gene Chr17:32338712-32401231 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023927
 protein coding gene Chr17:30400230-30464065 (+)
PWK/PhJ MGP_PWKPhJ_G0022455
 protein coding gene Chr17:28019560-28078540 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022273
 protein coding gene Chr17:28391069-28449520 (+)
WSB/EiJ MGP_WSBEiJ_G0022767
 protein coding gene Chr17:30360176-30421943 (+)



Homology
more
  • Human Ortholog
    ABCG1, ATP binding cassette subfamily G member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCG1, ATP binding cassette subfamily G member 1
  • Synonyms
    ABC8, WHITE1
  • Links
    NCBI Gene ID: 9619
    neXtProt AC: NX_P45844
    UniProt: P45844

  • Chr Location
    21q22.3; chr21:42199689-42297244 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 4 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal lipid homeostasis, increased numbers of multiple immune cell types, and abnormal response to a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1090
  • Tissues
    237
  • cDNA Data
    18
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11307 NCBI Gene Model | MGI Sequence Detail 60291 C57BL/6J ±  kb
    transcript NM_009593 RefSeq | MGI Sequence Detail 5821 C57BL/6  
    polypeptide Q64343 UniProt | EBI | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000003570 ATP-binding cassette sub-family G member 1
      (term hierarchy)
    • EC
      7.6.2.-
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR013525 ABC-2 type transporter, transmembrane domain
      IPR043926 ABC transporter family G domain
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR050352 ATP-binding cassette subfamily G transporters
      IPR005284 Pigment precursor permease/Protein ATP-binding cassette sub-family G
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q64343 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 18
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36280, MGI:2147064
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 11
      Diseases 3
      Gene Ontology 14
      Phenotypes 118
    • Earliest
      J:35459 Savary S, et al., Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene. Mamm Genome. 1996 Sep;7(9):673-6
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory