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Dnah5 Gene Detail
Summary
  • Symbol
    Dnah5
  • Name
    dynein, axonemal, heavy chain 5
  • Synonyms
    b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo, Dnahc5, Mdnah5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107718
    NCBI Gene: 110082
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:28203898-28472198 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 10.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7717 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107718
 protein coding gene Chr15:28155000-28472198 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021760
 protein coding gene Chr15:26297577-26573891 (+)
A/J MGP_AJ_G0021720
 protein coding gene Chr15:25300296-25558775 (+)
AKR/J MGP_AKRJ_G0021698
 protein coding gene Chr15:25887840-26156151 (+)
BALB/cJ MGP_BALBcJ_G0021727
 protein coding gene Chr15:25270219-25531899 (+)
C3H/HeJ MGP_C3HHeJ_G0021502
 protein coding gene Chr15:25935953-26207791 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022166
 protein coding gene Chr15:27348199-27633698 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019705
 protein coding gene Chr15:23544301-23841492 (+)
CAST/EiJ MGP_CASTEiJ_G0021018
 protein coding gene Chr15:26290749-26642235 (+)
CBA/J MGP_CBAJ_G0021471
 protein coding gene Chr15:28161979-28442373 (+)
DBA/2J MGP_DBA2J_G0021595
 protein coding gene Chr15:25046460-25301307 (+)
FVB/NJ MGP_FVBNJ_G0021573
 protein coding gene Chr15:24636939-24896016 (+)
LP/J MGP_LPJ_G0021664
 protein coding gene Chr15:26175924-26450858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021598
 protein coding gene Chr15:30893666-31181528 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022189
 protein coding gene Chr15:26111240-26380967 (+)
PWK/PhJ MGP_PWKPhJ_G0020762
 protein coding gene Chr15:25191836-25498054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020600
 protein coding gene Chr15:25868921-26193082 (+)
WSB/EiJ MGP_WSBEiJ_G0021074
 protein coding gene Chr15:26020455-26354113 (+)



Homology
more
  • Human Ortholog
    DNAH5, dynein axonemal heavy chain 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH5, dynein axonemal heavy chain 5
  • Synonyms
    CILD3, DNAHC5, HL1, KTGNR, PCD
  • Links
    NCBI Gene ID: 1767
    neXtProt AC: NX_Q8TE73
    UniProt: Q8TE73

  • Chr Location
    5p15.2; chr5:13690328-14011818 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with Dnah5 mouse models; 2 with human DNAH5 associations

Human Disease Mouse Models
      
IDs
 View 12 models
IDs
 View 14 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 9 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    15 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 16 alleles in 16 genetic backgrounds
    136 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    11
  • cDNA Data
    11
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022262 Ensembl Gene Model | MGI Sequence Detail 268301 C57BL/6J ±  kb
    transcript ENSMUST00000067048 Ensembl | MGI Sequence Detail 15637 Not Applicable  
    polypeptide ENSMUSP00000069751 Ensembl | MGI Sequence Detail 4621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006564 dynein axonemal heavy chain 5
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR013594 Dynein heavy chain, tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q8VHE6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36294, MGI:2146141, MGI:5311155, MGI:5311349, MGI:5311351, MGI:5430340, MGI:5433314, MGI:5648246
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 11
      Diseases 3
      Gene Ontology 17
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory