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Abr Gene Detail
Summary
  • Symbol
    Abr
  • Name
    active BCR-related gene
  • Synonyms
    6330400K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107771
    NCBI Gene: 109934
  • Alliance
    gene page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76307560-76468515 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107771
 protein coding gene Chr11:76307560-76514384 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018735
 protein coding gene Chr11:77247790-77457669 (-)
A/J MGP_AJ_G0018701
 protein coding gene Chr11:74362521-74562999 (-)
AKR/J MGP_AKRJ_G0018671
 protein coding gene Chr11:76620920-76827682 (-)
BALB/cJ MGP_BALBcJ_G0018675
 protein coding gene Chr11:74745103-74942310 (-)
C3H/HeJ MGP_C3HHeJ_G0018488
 protein coding gene Chr11:76632188-76836523 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019126
 protein coding gene Chr11:79678185-79898775 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016761
 protein coding gene Chr11:71362668-71557745 (-)
CAST/EiJ MGP_CASTEiJ_G0018042
 protein coding gene Chr11:77026174-77235297 (-)
CBA/J MGP_CBAJ_G0018458
 protein coding gene Chr11:83157577-83390754 (-)
DBA/2J MGP_DBA2J_G0018567
 protein coding gene Chr11:73958853-74159245 (-)
FVB/NJ MGP_FVBNJ_G0018557
 protein coding gene Chr11:73509199-73711113 (-)
LP/J MGP_LPJ_G0018638
 protein coding gene Chr11:77823811-78027307 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018583
 protein coding gene Chr11:83651461-83856343 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019166
 protein coding gene Chr11:76809292-77014241 (-)
PWK/PhJ MGP_PWKPhJ_G0017813
 protein coding gene Chr11:74684541-74892145 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017604
 protein coding gene Chr11:76381289-76598310 (-)
WSB/EiJ MGP_WSBEiJ_G0018095
 protein coding gene Chr11:76636578-76848302 (-)



Homology
more
  • Human Ortholog
    ABR, ABR activator of RhoGEF and GTPase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABR, ABR activator of RhoGEF and GTPase
  • Synonyms
    MDB
  • Links
    NCBI Gene ID: 29
    neXtProt AC: NX_Q12979
    UniProt: Q12979

  • Chr Location
    17p13.3; chr17:1003519-1229738 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    23 phenotype references
Homozygous null mutants are apparently normal, but double knockouts with Bcr show increased postnatal mortality, ataxia, hyperactivity, circling, lack of vestibular otoconia, ectopic cerebellar granule cells, and foliation defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    40
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1050
  • Tissues
    86
  • cDNA Data
    257
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 109934 NCBI Gene Model | MGI Sequence Detail 160956 C57BL/6J ±  kb
transcript NM_198895 RefSeq | MGI Sequence Detail 5242 ZRU/MplStud  
polypeptide Q5SSL4 UniProt | EBI | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 258
    cDNA 257
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36348, MGI:2144432
References
more
  • Summaries
    All 57
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory