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Hnrnpc Gene Detail
Summary
  • Symbol
    Hnrnpc
  • Name
    heterogeneous nuclear ribonucleoprotein C
  • Synonyms
    D14Wsu171e, hnRNP C1, hnRNPC1, hnRNP C2, hnRNPC2, Hnrpc, Hnrpc1, Hnrpc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107795
    NCBI Gene: 15381
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52310834-52341462 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.79 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    802 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107795
 protein coding gene Chr14:52310834-52341485 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021290
 protein coding gene Chr14:46089748-46134237 (-)
A/J MGP_AJ_G0021247
 protein coding gene Chr14:44893405-44922209 (-)
AKR/J MGP_AKRJ_G0021223
 protein coding gene Chr14:46511739-46544692 (-)
BALB/cJ MGP_BALBcJ_G0021251
 protein coding gene Chr14:44999597-45031842 (-)
C3H/HeJ MGP_C3HHeJ_G0021031
 protein coding gene Chr14:46329006-46358778 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021690
 protein coding gene Chr14:48127860-48171628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019234
 protein coding gene Chr14:44095466-44124837 (-)
CAST/EiJ MGP_CASTEiJ_G0020550
 protein coding gene Chr14:43296962-43326927 (-)
CBA/J MGP_CBAJ_G0020998
 protein coding gene Chr14:49603952-49634006 (-)
DBA/2J MGP_DBA2J_G0021119
 protein coding gene Chr14:44660854-44696849 (-)
FVB/NJ MGP_FVBNJ_G0021102
 protein coding gene Chr14:44248759-44279416 (-)
LP/J MGP_LPJ_G0021194
 protein coding gene Chr14:46695999-46728770 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021125
 protein coding gene Chr14:49051435-49081952 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021717
 protein coding gene Chr14:45901652-45930458 (-)
PWK/PhJ MGP_PWKPhJ_G0020299
 protein coding gene Chr14:41405736-41435779 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020126
 protein coding gene Chr14:41934702-41967465 (-)
WSB/EiJ MGP_WSBEiJ_G0020603
 protein coding gene Chr14:46218815-46254378 (-)



Homology
more
  • Human Ortholog
    HNRNPC, heterogeneous nuclear ribonucleoprotein C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPC, heterogeneous nuclear ribonucleoprotein C
  • Synonyms
    C1, C2, HNRNP, HNRPC, MRD74, SNRPC
  • Links
    NCBI Gene ID: 3183
    neXtProt AC: NX_P07910
    UniProt: P07910

  • Chr Location
    14q11.2; chr14:21209136-21269494 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HNRNPC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele fail to undergo gastrulation, appear to arrest at the egg cylinder stage, and are resorbed at various times thereafter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    45
  • cDNA Data
    29
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15381 NCBI Gene Model | MGI Sequence Detail 30629 C57BL/6J ±  kb
    transcript NM_001360173 RefSeq | MGI Sequence Detail 4021 C57BL/6  
    polypeptide Q9Z204 UniProt | EBI | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008662 heterogeneous nuclear ribonucleoproteins C1/C2
      (term hierarchy)
    • InterPro Domains
      IPR017347 Heterogeneous nuclear ribonucleoprotein C
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR051186 RRM HNRPC family, RALY subfamily
    • GlyGen
      Q9Z204 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 32
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28111, MGD-MRK-28112, MGD-MRK-36372, MGD-MRK-36437, MGI:104817, MGI:104818, MGI:107860, MGI:2146114
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:151685 von Melchner H, et al., Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992 Jun;6(6):919-27
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory