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Tuba1b Gene Detail
Summary
  • Symbol
    Tuba1b
  • Name
    tubulin, alpha 1B
  • Synonyms
    Tuba2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107804
    NCBI Gene: 22143
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98829310-98832271 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 55.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107804
 protein coding gene Chr15:98829306-98832446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023103
 protein coding gene Chr17:2205455-2207297 (-)
A/J MGP_AJ_G0022277
 protein coding gene Chr15:96826819-96835249 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0035096
 protein coding gene Chr9:88516917-88533968 (+)
C3H/HeJ MGP_C3HHeJ_G0022835
 protein coding gene Chr17:2257076-2259640 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020109
 protein coding gene Chr12:51457090-51459996 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029986
 protein coding gene Chr6:78982572-78984010 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0022146
 protein coding gene Chr15:96170005-96173427 (-)
FVB/NJ MGP_FVBNJ_G0034883
 protein coding gene Chr9:87414098-87415637 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018578
 protein coding gene Chr12:43700321-43703500 (-)
WSB/EiJ MGP_WSBEiJ_G0021625
 protein coding gene Chr15:100332443-100336012 (-)



Homology
more
  • Human Ortholog
    TUBA1B, tubulin alpha 1b
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA1B, tubulin alpha 1b
  • Synonyms
    K-ALPHA-1
  • Links
    NCBI Gene ID: 10376
    neXtProt AC: NX_P68363
    UniProt: P68363

  • Chr Location
    12q13.12; chr12:49127782-49131397 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Tuba1b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    12 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    29
  • cDNA Data
    24
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22143 NCBI Gene Model | MGI Sequence Detail 2962 C57BL/6J ±  kb
transcript NM_011654 RefSeq | MGI Sequence Detail 1747 Not Specified  
polypeptide P05213 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 25
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36381
References
more
  • Summaries
    All 67
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 13
    Phenotypes 23
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:340392 Ebeid M, et al., beta-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development. PLoS Genet. 2023 Aug;19(8):e1010925
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory