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Nptx1 Gene Detail
Summary
  • Symbol
    Nptx1
  • Name
    neuronal pentraxin 1
  • Synonyms
    D11Bwg1004e, Np1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107811
    NCBI Gene: 18164
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119429545-119438579 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.95 cM, cytoband E1-E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107811
 protein coding gene Chr11:119429545-119438646 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019484
 protein coding gene Chr11:123949563-123958597 (-)
A/J MGP_AJ_G0019452
 protein coding gene Chr11:118441618-118450652 (-)
AKR/J MGP_AKRJ_G0019422
 protein coding gene Chr11:122006549-122015583 (-)
BALB/cJ MGP_BALBcJ_G0019427
 protein coding gene Chr11:118799850-118808884 (-)
C3H/HeJ MGP_C3HHeJ_G0019233
 protein coding gene Chr11:122333925-122342991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019876
 protein coding gene Chr11:127720613-127731899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017501
 protein coding gene Chr11:115438527-115447558 (-)
CAST/EiJ MGP_CASTEiJ_G0018787
 protein coding gene Chr11:123802999-123812033 (-)
CBA/J MGP_CBAJ_G0019204
 protein coding gene Chr11:132697762-132709628 (-)
DBA/2J MGP_DBA2J_G0019316
 protein coding gene Chr11:117812668-117822213 (-)
FVB/NJ MGP_FVBNJ_G0019308
 protein coding gene Chr11:117490681-117499740 (-)
LP/J MGP_LPJ_G0019388
 protein coding gene Chr11:124267430-124276464 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019341
 protein coding gene Chr11:131595230-131604264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019915
 protein coding gene Chr11:122688820-122697854 (-)
PWK/PhJ MGP_PWKPhJ_G0018553
 protein coding gene Chr11:119221933-119230972 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018345
 protein coding gene Chr11:122451418-122460430 (-)
WSB/EiJ MGP_WSBEiJ_G0018839
 protein coding gene Chr11:122677143-122686208 (-)



Homology
more
  • Human Ortholog
    NPTX1, neuronal pentraxin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPTX1, neuronal pentraxin 1
  • Synonyms
    NP1, SCA50
  • Links
    NCBI Gene ID: 4884
    neXtProt AC: NX_Q15818
    UniProt: Q15818

  • Chr Location
    17q25.3; chr17:80466834-80477843 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NPTX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    43
  • cDNA Data
    24
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025582 Ensembl Gene Model | MGI Sequence Detail 9035 C57BL/6J ±  kb
transcript ENSMUST00000026670 Ensembl | MGI Sequence Detail 5217 Not Applicable  
polypeptide ENSMUSP00000026670 Ensembl | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011382 neuronal pentraxin-1
    (term hierarchy)
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    IPR051360 Neuronal Pentraxin and Related
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentraxin-related
  • GlyGen
    Q62443 3 sites, 13 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 24
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-34057, MGD-MRK-36388
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:35528 Omeis IA, et al., Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. Genomics. 1996 Sep 15;36(3):543-5
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory