About   Help   FAQ
Rock2 Gene Detail
Summary
  • Symbol
    Rock2
  • Name
    Rho-associated coiled-coil containing protein kinase 2
  • Synonyms
    B230113H15Rik, Rho-kinase, Rock2m, Rock-II, ROKalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:107926
    NCBI Gene: 19878
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:16944896-17037824 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.04 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1701 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107926
 protein coding gene Chr12:16944808-17038275 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019613
 protein coding gene Chr12:14300107-14395162 (+)
A/J MGP_AJ_G0019580
 protein coding gene Chr12:13800353-13894653 (+)
AKR/J MGP_AKRJ_G0019550
 protein coding gene Chr12:14455779-14548614 (+)
BALB/cJ MGP_BALBcJ_G0019556
 protein coding gene Chr12:14047158-14139974 (+)
C3H/HeJ MGP_C3HHeJ_G0019361
 protein coding gene Chr12:14360965-14460430 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020004
 protein coding gene Chr12:14775491-14882280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017630
 protein coding gene Chr12:13305779-13399973 (+)
CAST/EiJ MGP_CASTEiJ_G0018916
 protein coding gene Chr12:14244657-14344025 (+)
CBA/J MGP_CBAJ_G0019332
 protein coding gene Chr12:15583561-15681772 (+)
DBA/2J MGP_DBA2J_G0019445
 protein coding gene Chr12:13715282-13811671 (+)
FVB/NJ MGP_FVBNJ_G0019436
 protein coding gene Chr12:13603877-13699183 (+)
LP/J MGP_LPJ_G0019516
 protein coding gene Chr12:14419382-14515249 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019471
 protein coding gene Chr12:15463891-15568125 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020043
 protein coding gene Chr12:14142446-14237379 (+)
PWK/PhJ MGP_PWKPhJ_G0018682
 protein coding gene Chr12:13753761-13849428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018472
 protein coding gene Chr12:14352707-14446508 (+)
WSB/EiJ MGP_WSBEiJ_G0018967
 protein coding gene Chr12:14256412-14358866 (+)



Homology
more
  • Human Ortholog
    ROCK2, Rho associated coiled-coil containing protein kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROCK2, Rho associated coiled-coil containing protein kinase 2
  • Synonyms
    ROCK-II
  • Links
    NCBI Gene ID: 9475
    neXtProt AC: NX_O75116
    UniProt: O75116

  • Chr Location
    2p25.1; chr2:11179759-11348330 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this genes tend to die before birth; those that survive are small. Hemorrhaging occurs in the placenta, at the tips of hind limb buds and occasionally the tail. Subsequent development is normal and the size deficit is made up. They are fertile as adults.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    92
  • cDNA Data
    187
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020580 Ensembl Gene Model | MGI Sequence Detail 92929 C57BL/6J ±  kb
    transcript ENSMUST00000220688 Ensembl | MGI Sequence Detail 4357 Not Applicable  
    polypeptide ENSMUSP00000152813 Ensembl | MGI Sequence Detail 1444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 194
      cDNA 188
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36506, MGI:1925098
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 26
      Gene Ontology 27
      Phenotypes 42
    • Earliest
      J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
    • Latest
      J:350506 Akamine T, et al., Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice. FEBS Open Bio. 2024 Jun;14(6):906-921
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory