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Polr1b Gene Detail
Summary
  • Symbol
    Polr1b
  • Name
    polymerase (RNA) I polypeptide B
  • Synonyms
    128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108014
    NCBI Gene: 20017
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:128942915-128968514 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.68 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    861 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108014
 protein coding gene Chr2:128942891-128969980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026483
 protein coding gene Chr2:132475407-132502327 (+)
A/J MGP_AJ_G0026447
 protein coding gene Chr2:127107293-127133142 (+)
AKR/J MGP_AKRJ_G0026422
 protein coding gene Chr2:130716265-130742651 (+)
BALB/cJ MGP_BALBcJ_G0026459
 protein coding gene Chr2:127371967-127397449 (+)
C3H/HeJ MGP_C3HHeJ_G0026202
 protein coding gene Chr2:131224289-131253748 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026904
 protein coding gene Chr2:136618499-136648111 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024281
 protein coding gene Chr2:121933177-121957209 (+)
CAST/EiJ MGP_CASTEiJ_G0025663
 protein coding gene Chr2:131484572-131512158 (+)
CBA/J MGP_CBAJ_G0026182
 protein coding gene Chr2:141668697-141697790 (+)
DBA/2J MGP_DBA2J_G0026316
 protein coding gene Chr2:126496641-126522736 (+)
FVB/NJ MGP_FVBNJ_G0026280
 protein coding gene Chr2:125146895-125172862 (+)
LP/J MGP_LPJ_G0026421
 protein coding gene Chr2:132713991-132743543 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026300
 protein coding gene Chr2:145581284-145610811 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026959
 protein coding gene Chr2:130750958-130779026 (+)
PWK/PhJ MGP_PWKPhJ_G0025399
 protein coding gene Chr2:126073498-126099713 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025201
 protein coding gene Chr2:129861101-129888818 (+)
WSB/EiJ MGP_WSBEiJ_G0025737
 protein coding gene Chr2:131671868-131697693 (+)



Homology
more
  • Human Ortholog
    POLR1B, RNA polymerase I subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR1B, RNA polymerase I subunit B
  • Synonyms
    A135, RPA135, RPA2, Rpo1-2, TCS4
  • Links
    NCBI Gene ID: 84172
    neXtProt AC: NX_Q9H9Y6
    UniProt: Q9H9Y6

  • Chr Location
    2q14.1; chr2:112541915-112579818 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POLR1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality prior to implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    116
  • cDNA Data
    93
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027395 Ensembl Gene Model | MGI Sequence Detail 25600 C57BL/6J ±  kb
    transcript ENSMUST00000103205 Ensembl | MGI Sequence Detail 3998 Not Applicable  
    polypeptide ENSMUSP00000099494 Ensembl | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012983 DNA-directed RNA polymerase I subunit RPA2
      (term hierarchy)
    • EC
      2.7.7.6
    • InterPro Domains
      IPR009674 DNA-directed RNA polymerase I subunit RPA2, domain 4
      IPR015712 DNA-directed RNA polymerase, subunit 2
      IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
      IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
      IPR007121 RNA polymerase, beta subunit, conserved site
      IPR007644 RNA polymerase, beta subunit, protrusion
      IPR007642 RNA polymerase Rpb2, domain 2
      IPR037034 RNA polymerase Rpb2, domain 2 superfamily
      IPR007645 RNA polymerase Rpb2, domain 3
      IPR007641 RNA polymerase Rpb2, domain 7
      IPR014724 RNA polymerase Rpb2, OB-fold
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 93
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37048, MGI:2443763
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 15
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory