Ntsr2 MGI Mouse Gene Detail - MGI:108018 - neurotensin receptor 2

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Ntsr2 Gene Detail

Symbol

Ntsr2
Name

neurotensin receptor 2
Synonyms

NT2R, NTRL

Feature Type

protein coding gene
IDs

MGI:108018
NCBI Gene: 18217
Alliance

gene page
Transcription Start Sites

12 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr12:16703477-16710223 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 7.98 cM
Mapping Data

4 experiments

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SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_108018	protein coding gene	Chr12:16703383-16710228 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019610	protein coding gene	Chr12:14044968-14051684 (+)
A/J	MGP_AJ_G0019577	protein coding gene	Chr12:13554955-13561671 (+)
AKR/J	MGP_AKRJ_G0019547	protein coding gene	Chr12:14204335-14211062 (+)
BALB/cJ	MGP_BALBcJ_G0019553	protein coding gene	Chr12:13798460-13805176 (+)
C3H/HeJ	MGP_C3HHeJ_G0019358	protein coding gene	Chr12:14107430-14114150 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020001	protein coding gene	Chr12:14505530-14512382 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017627	protein coding gene	Chr12:13052029-13058773 (+)
CAST/EiJ	MGP_CASTEiJ_G0018913	protein coding gene	Chr12:13986984-13993695 (+)
CBA/J	MGP_CBAJ_G0019329	protein coding gene	Chr12:15305066-15311766 (+)
DBA/2J	MGP_DBA2J_G0019442	protein coding gene	Chr12:13470947-13477664 (+)
FVB/NJ	MGP_FVBNJ_G0019433	protein coding gene	Chr12:13356668-13363370 (+)
LP/J	MGP_LPJ_G0019513	protein coding gene	Chr12:14163395-14170112 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019468	protein coding gene	Chr12:15210442-15217160 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020040	protein coding gene	Chr12:13888883-13895599 (+)
PWK/PhJ	MGP_PWKPhJ_G0018679	protein coding gene	Chr12:13503523-13510327 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018469	protein coding gene	Chr12:14103009-14109732 (+)
WSB/EiJ	MGP_WSBEiJ_G0018964	protein coding gene	Chr12:14000557-14007275 (+)

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Human Ortholog

NTSR2, neurotensin receptor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTSR2, neurotensin receptor 2
Synonyms

NTR2
Links

HGNC:8040

NCBI Gene ID: 23620

neXtProt AC: NX_O95665

UniProt: O95665
Chr Location

2p25.1; chr2:11658178-11670195 (-) GRCh38

MGI Vertebrate Homology

Ntsr2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NTSR2
Gene Tree

Ntsr2

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice exhibit abnormal thermal nociception. Mice homozygous for different knock-out allele exhibit increased prepulse inhibition and decreased accoustic startle response.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

20
cDNA Data

7
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

57
RefSeq

12
UniProt

5
CCDS

CCDS36407.1, CCDS88315.1

Ensembl

ENSMUSG00000020591 (Evidence)
NCBI Gene

18217

Representative Sequences				Length	Strain/Species	Flank
	genomic	18217	NCBI Gene Model \| MGI Sequence Detail	6747	C57BL/6J	± kb
	transcript	NR_182023	RefSeq \| MGI Sequence Detail	3021	ZRU/MplStud
	polypeptide	P70310	UniProt \| EBI \| MGI Sequence Detail	416	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001628 neurotensin receptor type 2

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR003984 Neurotensin receptor

IPR003986 Neurotensin type 2 receptor

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All nucleic 10

Genomic 2

cDNA 8

Microarray probesets 3

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MGD-MRK-37053

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Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 14
Earliest

J:35254 Mazella J, et al., Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci. 1996 Sep 15;16(18):5613-20
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ntsr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112846	Chr12:16703476-16703487 (+)	5 bp
Tssr112847	Chr12:16703534-16703545 (+)	63 bp
Tssr112848	Chr12:16703570-16703584 (+)	100 bp
Tssr112849	Chr12:16703605-16703629 (+)	140 bp
Tssr112850	Chr12:16703710-16703764 (+)	260 bp
Tssr112851	Chr12:16703769-16703776 (+)	296 bp
Tssr112852	Chr12:16703798-16703809 (+)	327 bp
Tssr112853	Chr12:16703904-16703977 (+)	464 bp
Tssr112854	Chr12:16703989-16704004 (+)	520 bp
Tssr112855	Chr12:16706305-16706311 (+)	2,831 bp
Tssr112856	Chr12:16707903-16707918 (+)	4,434 bp
Tssr112857	Chr12:16707970-16707979 (+)	4,498 bp

Ntsr2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Fl1sa	Chr12, 13.69 cM		J:244215	Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. It was previously determined that SMXA-5 mice develop severe fatty liver on a high fat diet, although parental SM/J and A/J mice were resistant to fatty liver. Quantitative trait analysis using (SM/J x SMxA-5)F2 intercrossed mice identified a significant QTL, Fl1sa (fatty liver 1 in SMXA), for liver weight, liver triglyceride and total lipid content on centromere-53.06 Mb of mouse Chromosome 12. The A/J allele at Fl1sa was associated with the fatty liver. [J:124974] In a subsequent study using the livers from A/J-Chr 12 consomic and A/J mice that were fed a high fat diet three candidate genes were identified, Iah1, Rrm2 and Prkd1 using DNA microarray analysis. [J: 240255] The goal of the current study was to narrow the previously identified Fl1sa region by genetic dissection using novel congenic mice to identify candidate genes within the narrowed Fl1sa region. Two strains of congenic mice, A.SM-(centromere - D12Mit85)/J (R2) and A.SM-(D12Mit85-D12Mit112)/J (R3), were constructed from parental A/J and A/JChr 12 . Microsatellite markers and SNPs were used for the genotyping of R2 and R3 genomic DNA. Physical positions were taken from GRCm38.P4. The lipid accumulation in the respective livers was analyzed. As the liver triglyceride content in R2 and R3 congenic mice was significantly lower than in A/J mice. Male A/J, A/J-Chr12, R2 and R3 mice were fed standard chow until 6 weeks of age and thereafter fed a high fat diet from 6 to 13 weeks of age. At 13 weeks of age all mice were sacrificed after a 4 hour fast. The liver and white adipose tissue (subcutaneous fat, epididymal fat, mesenteric fat and retroperitoneal fat) were harvested and weighed. Blood sample were collected to measure serum lipids. Serum triglyceride, cholesterol and hepatic triglyceride content were measured. Whole transcripts from epididymal fats were measured using a Mouse Genome ST 2.0 array. Liver triglyceride content was significantly lower in A/J-Chr 12, R2 and R3 mice compared with that of A/J mice. Liver triglyceride and liver total lipid in R2 and R3 mice showed intermediate values between those of A/J and A/J-Chr 12 mice. The results suggested that the genes responsible for fatty liver existed in the SM/J region in strain R2 (centromere-29.20 Mb) and in the SM/J region in strain R3 (29.20-46.75 Mb) of Chromosome 12, Fig 1. Subsequently, in both of the narrowed Fl1sa regions microarray analysis of liver and epididymal fat from A/J and A/J-Chr 12 mice was performed in an attempt to identify candidate genes. Significant differences in gene expression levels in epididymal fat analysis were confirmed in 6 candidate genes: Ntsr2, Zfp125, Gdap10, Nrcam, Stxbp6 and Nova1 between the two strains.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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