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Scn10a Gene Detail
Summary
  • Symbol
    Scn10a
  • Name
    sodium channel, voltage-gated, type X, alpha
  • Synonyms
    Nav1.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108029
    NCBI Gene: 20264
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:119437522-119548388 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband distal
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3397 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108029
 protein coding gene Chr9:119437522-119548388 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035422
 protein coding gene Chr9:122399304-122514399 (-)
A/J MGP_AJ_G0035403
 protein coding gene Chr9:117833078-117942740 (-)
AKR/J MGP_AKRJ_G0035336
 protein coding gene Chr9:120916796-121025371 (-)
BALB/cJ MGP_BALBcJ_G0035399
 protein coding gene Chr9:117714294-117824639 (-)
C3H/HeJ MGP_C3HHeJ_G0035107
 protein coding gene Chr9:121377128-121490562 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035922
 protein coding gene Chr9:125735559-125852410 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032804
 protein coding gene Chr9:115034151-115142765 (-)
CAST/EiJ MGP_CASTEiJ_G0034411
 protein coding gene Chr9:121377830-121498366 (-)
CBA/J MGP_CBAJ_G0035074
 protein coding gene Chr9:130463604-130585071 (-)
DBA/2J MGP_DBA2J_G0035233
 protein coding gene Chr9:117276242-117386550 (-)
FVB/NJ MGP_FVBNJ_G0035180
 protein coding gene Chr9:116149345-116258966 (-)
LP/J MGP_LPJ_G0035312
 protein coding gene Chr9:122738086-122855257 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035221
 protein coding gene Chr9:131410951-131531725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035941
 protein coding gene Chr9:121296318-121409314 (-)
PWK/PhJ MGP_PWKPhJ_G0034116
 protein coding gene Chr9:117711731-117825763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033952
 protein coding gene Chr9:121398312-121509780 (-)
WSB/EiJ MGP_WSBEiJ_G0034531
 protein coding gene Chr9:121181427-121296464 (-)



Homology
more
  • Human Ortholog
    SCN10A, sodium voltage-gated channel alpha subunit 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN10A, sodium voltage-gated channel alpha subunit 10
  • Synonyms
    FEPS2, Nav1.8, PN3, SNS
  • Links
    NCBI Gene ID: 6336
    neXtProt AC: NX_Q9Y5Y9
    UniProt: Q9Y5Y9

  • Chr Location
    3p22.2; chr3:38696802-38816286 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SCN10A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1 images
    152 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired perception of pain. Mice homozygous or heterozygous for an ENU-induced allele exhibit a catalepsy phenotype following scruffing and increased sensitivity to cold pain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    14
  • cDNA Data
    7
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20264 NCBI Gene Model | MGI Sequence Detail 110867 C57BL/6J ±  kb
    transcript NM_001205321 RefSeq | MGI Sequence Detail 6416 ZRU/MplStud  
    polypeptide Q6QIY3 UniProt | EBI | MGI Sequence Detail 1958 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000002096 sodium channel protein type 10 subunit alpha
      (term hierarchy)
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR010526 Sodium ion transport-associated domain
      IPR027359 Voltage-dependent channel domain superfamily
      IPR043203 Voltage-gated cation channel calcium and sodium
      IPR001696 Voltage gated sodium channel, alpha subunit
      IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gate
    • GlyGen
      Q6QIY3 9 sites
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 9
      cDNA 7
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37065
    References
    more
    • Summaries
      All 205
      Developmental Gene Expression 20
      Gene Ontology 11
      Phenotypes 152
    • Earliest
      J:35911 Kozak CA, et al., Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse. Mamm Genome. 1996 Oct;7(10):787-8
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory