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Ccna1 Gene Detail
Summary
  • Symbol
    Ccna1
  • Name
    cyclin A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108042
    NCBI Gene: 12427
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54952890-54962922 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 26.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108042
 protein coding gene Chr3:54952890-54965055 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027219
 protein coding gene Chr3:53771976-53781993 (-)
A/J MGP_AJ_G0027179
 protein coding gene Chr3:52106262-52116361 (-)
AKR/J MGP_AKRJ_G0027149
 protein coding gene Chr3:53176821-53186811 (-)
BALB/cJ MGP_BALBcJ_G0027192
 protein coding gene Chr3:51957286-51967267 (-)
C3H/HeJ MGP_C3HHeJ_G0026935
 protein coding gene Chr3:53386986-53397449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027638
 protein coding gene Chr3:55805183-55815188 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024997
 protein coding gene Chr3:48622727-48632761 (-)
CAST/EiJ MGP_CASTEiJ_G0026387
 protein coding gene Chr3:53529439-53539460 (-)
CBA/J MGP_CBAJ_G0026911
 protein coding gene Chr3:57595865-57605842 (-)
DBA/2J MGP_DBA2J_G0027045
 protein coding gene Chr3:51659116-51669168 (-)
FVB/NJ MGP_FVBNJ_G0027013
 protein coding gene Chr3:50644850-50654819 (-)
LP/J MGP_LPJ_G0027157
 protein coding gene Chr3:54476076-54486108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027031
 protein coding gene Chr3:61707226-61717223 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027696
 protein coding gene Chr3:53093640-53104643 (-)
PWK/PhJ MGP_PWKPhJ_G0026119
 protein coding gene Chr3:51330975-51341014 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025932
 protein coding gene Chr3:52846618-52856759 (-)
WSB/EiJ MGP_WSBEiJ_G0026461
 protein coding gene Chr3:53219192-53229159 (-)



Homology
more
  • Human Ortholog
    CCNA1, cyclin A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCNA1, cyclin A1
  • Synonyms
    CT146
  • Links
    NCBI Gene ID: 8900
    neXtProt AC: NX_P78396
    UniProt: P78396

  • Chr Location
    13q13.3; chr13:36431517-36442870 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CCNA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile due to the arrest of spermatogenesis prior to the first meiotic division. Female mutant mice are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    25
  • cDNA Data
    8
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027793 Ensembl Gene Model | MGI Sequence Detail 10033 C57BL/6J ±  kb
    transcript ENSMUST00000029368 Ensembl | MGI Sequence Detail 1560 Not Applicable  
    polypeptide ENSMUSP00000029368 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 8
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37078
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:336417 Chong D, et al., Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory