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Bag1 Gene Detail
Summary
  • Symbol
    Bag1
  • Name
    BCL2-associated athanogene 1
  • Synonyms
    Rap46
  • Feature Type
    protein coding gene
  • IDs
    MGI:108047
    NCBI Gene: 12017
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40936398-40948294 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.67 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    394 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108047
 protein coding gene Chr4:40936398-40948294 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028150
 protein coding gene Chr4:38847074-38858974 (-)
A/J MGP_AJ_G0028108
 protein coding gene Chr4:37380125-37392022 (-)
AKR/J MGP_AKRJ_G0028071
 protein coding gene Chr4:38336744-38348667 (-)
BALB/cJ MGP_BALBcJ_G0028120
 protein coding gene Chr4:37710856-37722756 (-)
C3H/HeJ MGP_C3HHeJ_G0027848
 protein coding gene Chr4:38876317-38889131 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028561
 protein coding gene Chr4:40280025-40291921 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025902
 protein coding gene Chr4:35032970-35044748 (-)
CAST/EiJ MGP_CASTEiJ_G0027304
 protein coding gene Chr4:38531906-38544106 (-)
CBA/J MGP_CBAJ_G0027820
 protein coding gene Chr4:41653795-41665695 (-)
DBA/2J MGP_DBA2J_G0027964
 protein coding gene Chr4:37299582-37311482 (-)
FVB/NJ MGP_FVBNJ_G0027931
 protein coding gene Chr4:36634809-36646709 (-)
LP/J MGP_LPJ_G0028072
 protein coding gene Chr4:38914845-38926745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027964
 protein coding gene Chr4:44987599-44999496 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028620
 protein coding gene Chr4:38450733-38462633 (-)
PWK/PhJ MGP_PWKPhJ_G0027023
 protein coding gene Chr4:37303323-37315978 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026850
 protein coding gene Chr4:38144211-38156148 (-)
WSB/EiJ MGP_WSBEiJ_G0027380
 protein coding gene Chr4:38405416-38417298 (-)



Homology
more
  • Human Ortholog
    BAG1, BAG cochaperone 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAG1, BAG cochaperone 1
  • Synonyms
    BAG-1, HAP, RAP46
  • Links
    NCBI Gene ID: 573
    neXtProt AC: NX_Q99933
    UniProt: Q99933

  • Chr Location
    9p13.3; chr9:33247820-33264720 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BAG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality and liver hypoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    56
  • cDNA Data
    139
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12017 NCBI Gene Model | MGI Sequence Detail 11897 C57BL/6J ±  kb
    transcript NM_009736 RefSeq | MGI Sequence Detail 1365 Not Specified  
    polypeptide Q60739 UniProt | EBI | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 139
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37083
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:34759 Takayama S, et al., Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 1995 Jan 27;80(2):279-84
    • Latest
      J:352269 Inose-Maruyama A, et al., Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. Cell Stress Chaperones. 2024;29(3):497-509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory