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Mlx Gene Detail
Summary
  • Symbol
    Mlx
  • Name
    MAX-like protein X
  • Synonyms
    bHLHd13, BigMax alpha, Tcfl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:108398
    NCBI Gene: 21428
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100978116-100983033 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.18 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108398
 protein coding gene Chr11:100978103-100983033 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019179
 protein coding gene Chr11:103898099-103903029 (+)
A/J MGP_AJ_G0019147
 protein coding gene Chr11:99544555-99549485 (+)
AKR/J MGP_AKRJ_G0019116
 protein coding gene Chr11:102641588-102646518 (+)
BALB/cJ MGP_BALBcJ_G0019121
 protein coding gene Chr11:100039063-100043993 (+)
C3H/HeJ MGP_C3HHeJ_G0018930
 protein coding gene Chr11:102811510-102816440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019570
 protein coding gene Chr11:107113218-107118148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017196
 protein coding gene Chr11:96962694-96967618 (+)
CAST/EiJ MGP_CASTEiJ_G0018484
 protein coding gene Chr11:103799777-103804753 (+)
CBA/J MGP_CBAJ_G0018899
 protein coding gene Chr11:111577055-111581985 (+)
DBA/2J MGP_DBA2J_G0019011
 protein coding gene Chr11:99079568-99084498 (+)
FVB/NJ MGP_FVBNJ_G0019001
 protein coding gene Chr11:98622913-98627843 (+)
LP/J MGP_LPJ_G0019080
 protein coding gene Chr11:104447958-104452888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019032
 protein coding gene Chr11:111145595-111150525 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019608
 protein coding gene Chr11:102961130-102966060 (+)
PWK/PhJ MGP_PWKPhJ_G0018247
 protein coding gene Chr11:100130251-100135269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018039
 protein coding gene Chr11:102696242-102701177 (+)
WSB/EiJ MGP_WSBEiJ_G0018533
 protein coding gene Chr11:102959498-102964428 (+)



Homology
more
  • Human Ortholog
    MLX, MAX dimerization protein MLX
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLX, MAX dimerization protein MLX
  • Synonyms
    bHLHd13, MAD7, MXD7, TCFL4, TF4
  • Links
    NCBI Gene ID: 6945
    neXtProt AC: NX_Q9UH92
    UniProt: Q9UH92

  • Chr Location
    17q21.2; chr17:42567072-42573239 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mlx mouse models; 1 with human MLX associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    208
  • cDNA Data
    19
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21428 NCBI Gene Model | MGI Sequence Detail 4918 C57BL/6J ±  kb
    transcript NM_011550 RefSeq | MGI Sequence Detail 1992 C57BL/6  
    polypeptide O08609 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-37440, MGI:1861754
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:37128 Bjerknes M, et al., TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. Gene. 1996 Nov 28;181(1-2):7-11
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory