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Plpp1 Gene Detail
Summary
  • Symbol
    Plpp1
  • Name
    phospholipid phosphatase 1
  • Synonyms
    Hpic53, Lipid phosphate phosphatase 1, LPP-1, LPP1, mPAP, Ppap2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:108412
    NCBI Gene: 19012
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:112937326-113004428 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.93 cM, cytoband D2.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2287 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108412
 protein coding gene Chr13:112937311-113004428 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020940
 protein coding gene Chr13:115377447-115455601 (+)
A/J MGP_AJ_G0020890
 protein coding gene Chr13:110776809-110845681 (+)
AKR/J MGP_AKRJ_G0020865
 protein coding gene Chr13:114118331-114192029 (+)
BALB/cJ MGP_BALBcJ_G0020890
 protein coding gene Chr13:111473597-111541177 (+)
C3H/HeJ MGP_C3HHeJ_G0020679
 protein coding gene Chr13:113916654-113987591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021326
 protein coding gene Chr13:118809831-118880630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018895
 protein coding gene Chr13:106073564-106139572 (+)
CAST/EiJ MGP_CASTEiJ_G0020199
 protein coding gene Chr13:113540337-113616641 (+)
CBA/J MGP_CBAJ_G0020641
 protein coding gene Chr13:123405703-123483090 (+)
DBA/2J MGP_DBA2J_G0020764
 protein coding gene Chr13:110489973-110557403 (+)
FVB/NJ MGP_FVBNJ_G0020748
 protein coding gene Chr13:109184342-109253366 (+)
LP/J MGP_LPJ_G0020840
 protein coding gene Chr13:115429037-115498636 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020776
 protein coding gene Chr13:123668924-123736098 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021362
 protein coding gene Chr13:113579946-113654174 (+)
PWK/PhJ MGP_PWKPhJ_G0019952
 protein coding gene Chr13:109230745-109305974 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019774
 protein coding gene Chr13:109898753-109969658 (+)
WSB/EiJ MGP_WSBEiJ_G0020256
 protein coding gene Chr13:114175974-114252354 (+)



Homology
more
  • Human Ortholog
    PLPP1, phospholipid phosphatase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLPP1, phospholipid phosphatase 1
  • Synonyms
    LLP1a, LPP1, PAP2, PAP-2a, PPAP2A
  • Links
    NCBI Gene ID: 8611
    neXtProt AC: NX_O14494
    UniProt: O14494

  • Chr Location
    5q11.2; chr5:55424854-55534969 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele are viable and fertile with elevated plasma levels of lysophosphatidic acid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    99
  • cDNA Data
    46
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021759 Ensembl Gene Model | MGI Sequence Detail 67103 C57BL/6J ±  kb
    transcript ENSMUST00000016144 Ensembl | MGI Sequence Detail 1598 Not Applicable  
    polypeptide ENSMUSP00000016144 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 46
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26084, MGD-MRK-37455, MGI:104646
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 14
      Phenotypes 10
    • Earliest
      J:28807 Egawa K, et al., Isolation of a novel ras-recision gene that is induced by hydrogen peroxide from a mouse osteoblastic cell line, MC3T3-E1. FEBS Lett. 1995 Sep 18;372(1):74-7
    • Latest
      J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory