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Amot Gene Detail
Summary
  • Symbol
    Amot
  • Name
    angiomotin
  • Synonyms
    D0Kist1, E230009N18Rik, mKIAA1071, Sii6
  • Feature Type
    protein coding gene
  • IDs
    MGI:108440
    NCBI Gene: 27494
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:144229420-144288145 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 66.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108440
 protein coding gene ChrX:144229420-144288177 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036162
 protein coding gene ChrX:143003355-143062571 (-)
A/J MGP_AJ_G0036139
 protein coding gene ChrX:142332603-142392664 (-)
AKR/J MGP_AKRJ_G0036065
 protein coding gene ChrX:146970129-147035637 (-)
BALB/cJ MGP_BALBcJ_G0036130
 protein coding gene ChrX:140542701-140601359 (-)
C3H/HeJ MGP_C3HHeJ_G0035838
 protein coding gene ChrX:143129274-143189875 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036654
 protein coding gene ChrX:147044752-147105345 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033477
 protein coding gene ChrX:133820225-133878612 (-)
CAST/EiJ MGP_CASTEiJ_G0035129
 protein coding gene ChrX:123709067-123771028 (-)
CBA/J MGP_CBAJ_G0035815
 protein coding gene ChrX:151571528-151633760 (-)
DBA/2J MGP_DBA2J_G0035973
 protein coding gene ChrX:141391665-141450273 (-)
FVB/NJ MGP_FVBNJ_G0035907
 protein coding gene ChrX:140604361-140664063 (-)
LP/J MGP_LPJ_G0036064
 protein coding gene ChrX:143953345-144013106 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035943
 protein coding gene ChrX:159451339-159513573 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036690
 protein coding gene ChrX:142299242-142358185 (-)
PWK/PhJ MGP_PWKPhJ_G0034823
 protein coding gene ChrX:120459391-120518937 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034649
 protein coding gene ChrX:124265707-124326016 (-)
WSB/EiJ MGP_WSBEiJ_G0035264
 protein coding gene ChrX:140646991-140705690 (-)



Homology
more
  • Human Ortholog
    AMOT, angiomotin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMOT, angiomotin
  • Links
    NCBI Gene ID: 154796
    neXtProt AC: NX_Q4VCS5
    UniProt: Q4VCS5

  • Chr Location
    Xq23; chrX:112774503-112840831 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null mutation exhibit impaired migration into proximal extraembryonic regions resulting in furrows of visceral endoderm at the junction of embryonic and extraembryonic regions, vascular insufficiency in the intersomitic region, dilated vessels in the brain and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    9
  • cDNA Data
    77
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27494 NCBI Gene Model | MGI Sequence Detail 58726 C57BL/6J ±  kb
    transcript NM_001403388 RefSeq | MGI Sequence Detail 7827 C57BL/6  
    polypeptide Q8VHG2 UniProt | EBI | MGI Sequence Detail 1126 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 77
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37484, MGI:2148071, MGI:2180948, MGI:2442022
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 6
    • Earliest
      J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
    • Latest
      J:336153 Skory RM, et al., The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization. Nat Commun. 2023 May 29;14(1):3101
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory