Acaca MGI Mouse Gene Detail - MGI:108451 - acetyl-Coenzyme A carboxylase alpha

Symbol

Acaca
Name

acetyl-Coenzyme A carboxylase alpha
Synonyms

A530025K05Rik, Acac, Acc1, acetyl-CoA carboxylase, LOC327983

Feature Type

protein coding gene
IDs

MGI:108451
NCBI Gene: 107476
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr11:84020498-84292477 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.29 cM
Mapping Data

5 experiments

SNPs within 2kb

5673 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108451	protein coding gene	Chr11:84020461-84292477 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018867	protein coding gene	Chr11:85532884-85814142 (+)
A/J	MGP_AJ_G0018834	protein coding gene	Chr11:82282522-82554657 (+)
AKR/J	MGP_AKRJ_G0018804	protein coding gene	Chr11:84702306-84996555 (+)
BALB/cJ	MGP_BALBcJ_G0018807	protein coding gene	Chr11:82666961-82937476 (+)
C3H/HeJ	MGP_C3HHeJ_G0018621	protein coding gene	Chr11:84758494-85032253 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019259	protein coding gene	Chr11:88120419-88425793 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016892	protein coding gene	Chr11:79370578-79642478 (+)
CAST/EiJ	MGP_CASTEiJ_G0018176	protein coding gene	Chr11:85392609-85680895 (+)
CBA/J	MGP_CBAJ_G0018592	protein coding gene	Chr11:91890587-92196819 (+)
DBA/2J	MGP_DBA2J_G0018700	protein coding gene	Chr11:81858841-82132404 (+)
FVB/NJ	MGP_FVBNJ_G0018689	protein coding gene	Chr11:81330747-81610533 (+)
LP/J	MGP_LPJ_G0018770	protein coding gene	Chr11:86063148-86349851 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018716	protein coding gene	Chr11:92045331-92347144 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019299	protein coding gene	Chr11:84987284-85272384 (+)
PWK/PhJ	MGP_PWKPhJ_G0017945	protein coding gene	Chr11:82616250-82898035 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017737	protein coding gene	Chr11:84528320-84818153 (+)
WSB/EiJ	MGP_WSBEiJ_G0018227	protein coding gene	Chr11:84832003-85116441 (+)

Human Ortholog

ACACA, acetyl-CoA carboxylase alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACACA, acetyl-CoA carboxylase alpha
Synonyms

ACAC, Acac1, ACACAD, ACACalpha, ACC, ACC1, ACCA, ACCalpha, hACC1
Links

HGNC:84

NCBI Gene ID: 31

neXtProt AC: NX_Q13085

UniProt: Q13085
Chr Location

17q12; chr17:37084992-37406836 (-) GRCh38

MGI Vertebrate Homology

Acaca stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACACA
Gene Tree

Acaca

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Phenotype Summary

24 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

22
Targeted

10
Genomic Mutations

3 involving Acaca
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

128 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality before embryo turning with growth arrest at the egg cylinder stage.

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All GO Annotations

39
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1047
Tissues

138
cDNA Data

119
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acaca

ZFIN acaca

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All Sequences

94
RefSeq

29
UniProt

7
CCDS

CCDS25185.1

Ensembl

ENSMUSG00000020532 (Evidence)
NCBI Gene

107476

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020532	Ensembl Gene Model \| MGI Sequence Detail	271980	C57BL/6J	± kb
transcript	ENSMUST00000020843	Ensembl \| MGI Sequence Detail	9026	Not Applicable
polypeptide	ENSMUSP00000020843	Ensembl \| MGI Sequence Detail	2345	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003596 acetyl-CoA carboxylase 1

(term hierarchy)
EC

6.4.1.2
InterPro Domains

IPR049076 Acetyl-CoA carboxylase

IPR049074 Acetyl-CoA carboxylase, BT domain

IPR013537 Acetyl-CoA carboxylase, central domain

IPR034733 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal

IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal

IPR011761 ATP-grasp fold

IPR013815 ATP-grasp fold, subdomain 1

IPR001882 Biotin-binding site

IPR005482 Biotin carboxylase, C-terminal

IPR005481 Biotin carboxylase-like, N-terminal domain

IPR011764 Biotin carboxylation domain

IPR000089 Biotin/lipoyl attachment

IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain

IPR029045 ClpP/crotonase-like domain superfamily

IPR016185 Pre-ATP-grasp domain superfamily

IPR011054 Rudiment single hybrid motif

IPR011053 Single hybrid motif
GlyGen

Q5SWU9 5 sites, 1 O-linked glycan (5 sites)

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All nucleic 127

cDNA 122

Primer pair 5

Microarray probesets 5

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MGD-MRK-37495, MGI:2443466, MGI:2685584

Summaries

All 132

Developmental Gene Expression 28

Gene Ontology 13

Phenotypes 47
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346743 Deja S, et al., Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. Cell Metab. 2024 Mar 1;

TSS for Acaca:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103788	Chr11:84020475-84020531 (+)	5 bp
Tssr103789	Chr11:84020551-84020558 (+)	57 bp
Tssr103790	Chr11:84020563-84020581 (+)	74 bp
Tssr103791	Chr11:84020583-84020610 (+)	99 bp
Tssr3619	Chr11:84051747-84051749 (+)	31,250 bp
Tssr103792	Chr11:84064117-84064130 (+)	43,626 bp
Tssr103793	Chr11:84064174-84064189 (+)	43,684 bp
Tssr103794	Chr11:84064276-84064286 (+)	43,783 bp
Tssr103795	Chr11:84064298-84064320 (+)	43,811 bp
Tssr103796	Chr11:84064322-84064351 (+)	43,839 bp
Tssr103797	Chr11:84068456-84068479 (+)	47,970 bp
Tssr103798	Chr11:84070437-84070483 (+)	49,962 bp
Tssr103799	Chr11:84070484-84070513 (+)	50,001 bp
Tssr103800	Chr11:84070618-84070675 (+)	50,149 bp
Tssr103801	Chr11:84070678-84070689 (+)	50,186 bp
Tssr103802	Chr11:84070692-84070703 (+)	50,200 bp
Tssr103803	Chr11:84071135-84071186 (+)	50,663 bp
Tssr103804	Chr11:84140224-84140238 (+)	119,733 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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