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Oxtr Gene Detail
Summary
  • Symbol
    Oxtr
  • Name
    oxytocin receptor
  • Synonyms
    OTR
  • Feature Type
    protein coding gene
  • IDs
    MGI:109147
    NCBI Gene: 18430
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:112450644-112466904 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.27 cM, cytoband E3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109147
 protein coding gene Chr6:112450644-112467800 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031108
 protein coding gene Chr6:114918413-114934547 (-)
A/J MGP_AJ_G0031077
 protein coding gene Chr6:110536446-110552624 (-)
AKR/J MGP_AKRJ_G0031008
 protein coding gene Chr6:113512502-113528725 (-)
BALB/cJ MGP_BALBcJ_G0031088
 protein coding gene Chr6:110491619-110508656 (-)
C3H/HeJ MGP_C3HHeJ_G0030620
 protein coding gene Chr6:70782563-70798790 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031547
 protein coding gene Chr6:117933775-117951272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028711
 protein coding gene Chr6:107566414-107583017 (-)
CAST/EiJ MGP_CASTEiJ_G0030195
 protein coding gene Chr6:113947717-113967421 (-)
CBA/J MGP_CBAJ_G0030774
 protein coding gene Chr6:122568491-122584691 (-)
DBA/2J MGP_DBA2J_G0030927
 protein coding gene Chr6:109642280-109658492 (-)
FVB/NJ MGP_FVBNJ_G0030881
 protein coding gene Chr6:108626763-108646153 (-)
LP/J MGP_LPJ_G0031007
 protein coding gene Chr6:114976590-114995089 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030915
 protein coding gene Chr6:126878883-126897654 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031574
 protein coding gene Chr6:113530633-113546845 (-)
PWK/PhJ MGP_PWKPhJ_G0029911
 protein coding gene Chr6:108579111-108596292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029739
 protein coding gene Chr6:112328694-112348434 (-)
WSB/EiJ MGP_WSBEiJ_G0030279
 protein coding gene Chr6:113891850-113909054 (-)



Homology
more
  • Human Ortholog
    OXTR, oxytocin receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OXTR, oxytocin receptor
  • Synonyms
    OT-R, OTR
  • Links
    NCBI Gene ID: 5021
    neXtProt AC: NX_P30559
    UniProt: P30559

  • Chr Location
    3p25.3; chr3:8741269-8769628 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 6 genetic backgrounds
    112 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1484
  • Tissues
    89
  • cDNA Data
    13
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049112 Ensembl Gene Model | MGI Sequence Detail 16261 C57BL/6J ±  kb
    transcript ENSMUST00000053306 Ensembl | MGI Sequence Detail 4704 Not Applicable  
    polypeptide ENSMUSP00000051132 Ensembl | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 3
      cDNA 13
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38191
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 18
      Gene Ontology 6
      Phenotypes 112
    • Earliest
      J:33726 Kaluz S, et al., Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene. Gene. 1996 Jun 26;172(2):313-4
    • Latest
      J:358178 Zhang Y, et al., Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ. Cell. 2024 Oct 17;187(21):6104-6122.e25
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory