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Fgf13 Gene Detail
Summary
  • Symbol
    Fgf13
  • Name
    fibroblast growth factor 13
  • Synonyms
    Fhf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109178
    NCBI Gene: 14168
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:58107505-58613431 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 33.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9833 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109178
 protein coding gene ChrX:58107499-58630932 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035754
 protein coding gene ChrX:54406793-54926109 (-)
A/J MGP_AJ_G0035736
 protein coding gene ChrX:54627487-55135002 (-)
AKR/J MGP_AKRJ_G0035656
 protein coding gene ChrX:56055766-56610066 (-)
BALB/cJ MGP_BALBcJ_G0035723
 protein coding gene ChrX:54001738-54503807 (-)
C3H/HeJ MGP_C3HHeJ_G0035425
 protein coding gene ChrX:54952759-55470756 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036252
 protein coding gene ChrX:55856482-56393116 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033104
 protein coding gene ChrX:54497445-54998443 (-)
CAST/EiJ MGP_CASTEiJ_G0034718
 protein coding gene ChrX:40748131-41262631 (-)
CBA/J MGP_CBAJ_G0035400
 protein coding gene ChrX:57504048-58043930 (-)
DBA/2J MGP_DBA2J_G0035554
 protein coding gene ChrX:54196690-54697270 (-)
FVB/NJ MGP_FVBNJ_G0035504
 protein coding gene ChrX:53753615-54254524 (-)
LP/J MGP_LPJ_G0035642
 protein coding gene ChrX:55014192-55517281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035540
 protein coding gene ChrX:59068069-59596398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036268
 protein coding gene ChrX:54444697-54962518 (-)
PWK/PhJ MGP_PWKPhJ_G0034413
 protein coding gene ChrX:38972289-39476564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034258
 protein coding gene ChrX:41557083-42097692 (-)
WSB/EiJ MGP_WSBEiJ_G0034861
 protein coding gene ChrX:53924989-54451225 (-)



Homology
more
  • Human Ortholog
    FGF13, fibroblast growth factor 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF13, fibroblast growth factor 13
  • Synonyms
    DEE90, FGF-13, FGF2, FHF-2, FHF2, LINC00889, XLID110
  • Links
    NCBI Gene ID: 2258
    neXtProt AC: NX_Q92913
    UniProt: Q92913

  • Chr Location
    Xq26.3-q27.1; chrX:138614727-139222777 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgf13 mouse models; 2 with human FGF13 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 5 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizgyous for a null allele die by E12.5. Heterozyous females for this allele develop spontaneous seizures and have increased susceptibility to hyperthermia-induced seizures and epilepsy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1007
  • Tissues
    197
  • cDNA Data
    29
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031137 Ensembl Gene Model | MGI Sequence Detail 505927 C57BL/6J ±  kb
    transcript ENSMUST00000033473 Ensembl | MGI Sequence Detail 2499 Not Applicable  
    polypeptide ENSMUSP00000033473 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 2
      cDNA 30
      Primer pair 10
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38222
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory