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Kif21b Gene Detail
Summary
  • Symbol
    Kif21b
  • Name
    kinesin family member 21B
  • Synonyms
    2610511N21Rik, mKIAA0449, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109234
    NCBI Gene: 16565
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:136059127-136105736 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 59.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1251 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109234
 protein coding gene Chr1:136059127-136105739 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016536
 protein coding gene Chr1:139932873-139982611 (+)
A/J MGP_AJ_G0016519
 protein coding gene Chr1:134638732-134686147 (+)
AKR/J MGP_AKRJ_G0016484
 protein coding gene Chr1:138642775-138689342 (+)
BALB/cJ MGP_BALBcJ_G0016479
 protein coding gene Chr1:134967861-135015164 (+)
C3H/HeJ MGP_C3HHeJ_G0016305
 protein coding gene Chr1:138737282-138783823 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016940
 protein coding gene Chr1:144960556-145012490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014651
 protein coding gene Chr1:127741538-127788559 (+)
CAST/EiJ MGP_CASTEiJ_G0015885
 protein coding gene Chr1:137831297-137878518 (+)
CBA/J MGP_CBAJ_G0016278
 protein coding gene Chr1:149985679-150034331 (+)
DBA/2J MGP_DBA2J_G0016384
 protein coding gene Chr1:133633324-133679607 (+)
FVB/NJ MGP_FVBNJ_G0016383
 protein coding gene Chr1:132279440-132325849 (+)
LP/J MGP_LPJ_G0016455
 protein coding gene Chr1:141161154-141211554 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016408
 protein coding gene Chr1:155621550-155669582 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016976
 protein coding gene Chr1:138407178-138454699 (+)
PWK/PhJ MGP_PWKPhJ_G0015671
 protein coding gene Chr1:132677584-132725546 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015458
 protein coding gene Chr1:137394286-137441141 (+)
WSB/EiJ MGP_WSBEiJ_G0015948
 protein coding gene Chr1:138451285-138499062 (+)



Homology
more
  • Human Ortholog
    KIF21B, kinesin family member 21B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF21B, kinesin family member 21B
  • Links
    NCBI Gene ID: 23046
    neXtProt AC: NX_O75037
    UniProt: O75037

  • Chr Location
    1q32.1; chr1:200969390-201023714 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO reduces dendrite branching and spine density as a result of reduced microtubule growth, resulting in impaired spatial learning and cued conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    30
  • cDNA Data
    186
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041642 Ensembl Gene Model | MGI Sequence Detail 46610 C57BL/6J ±  kb
    transcript ENSMUST00000130864 Ensembl | MGI Sequence Detail 9254 Not Applicable  
    polypeptide ENSMUSP00000114297 Ensembl | MGI Sequence Detail 1639 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009300 kinesin-like protein KIF21B
      (term hierarchy)
    • InterPro Domains
      IPR027640 Kinesin-like protein
      IPR001752 Kinesin motor domain
      IPR019821 Kinesin motor domain, conserved site
      IPR036961 Kinesin motor domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
      IPR050349 WD repeat LIS1/nudF dynein regulation
    • GlyGen
      Q9QXL1 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 186
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38278, MGI:2443746
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory