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Slpi Gene Detail
Summary
  • Symbol
    Slpi
  • Name
    secretory leukocyte peptidase inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109297
    NCBI Gene: 20568
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164195990-164231015 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.16 cM, cytoband H
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109297
 protein coding gene Chr2:164195990-164231086 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026848
 protein coding gene Chr2:169783327-169822264 (-)
A/J MGP_AJ_G0026814
 protein coding gene Chr2:162877824-162916395 (-)
AKR/J MGP_AKRJ_G0026785
 protein coding gene Chr2:167721979-167758856 (-)
BALB/cJ MGP_BALBcJ_G0026823
 protein coding gene Chr2:163240472-163278220 (-)
C3H/HeJ MGP_C3HHeJ_G0026565
 protein coding gene Chr2:168076651-168112606 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027271
 protein coding gene Chr2:174702597-174741818 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024641
 protein coding gene Chr2:156291262-156325906 (-)
CAST/EiJ MGP_CASTEiJ_G0026025
 protein coding gene Chr2:168492232-168531553 (-)
CBA/J MGP_CBAJ_G0026542
 protein coding gene Chr2:181038483-181078758 (-)
DBA/2J MGP_DBA2J_G0026680
 protein coding gene Chr2:162052772-162088614 (-)
FVB/NJ MGP_FVBNJ_G0026646
 protein coding gene Chr2:160459696-160499932 (-)
LP/J MGP_LPJ_G0026783
 protein coding gene Chr2:169869741-169912140 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026666
 protein coding gene Chr2:184643153-184683161 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027327
 protein coding gene Chr2:167623677-167660227 (-)
PWK/PhJ MGP_PWKPhJ_G0025760
 protein coding gene Chr2:161626123-161663259 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025561
 protein coding gene Chr2:166490565-166532620 (-)
WSB/EiJ MGP_WSBEiJ_G0026096
 protein coding gene Chr2:168476709-168516632 (-)



Homology
more
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
  • Synonyms
    ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4
  • Links
    NCBI Gene ID: 6590
    neXtProt AC: NX_P03973
    UniProt: P03973

  • Chr Location
    20q13.12; chr20:45252239-45254564 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice been independently reported to exhibit increased susceptibility to LPS-induced endotoxin shock with elevated production of IL-6, impaired cutaneous wound healing with increased inflammation and elastase activity, and high susceptibility to pulmonary mycobacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    4
  • cDNA Data
    26
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017002 Ensembl Gene Model | MGI Sequence Detail 35026 C57BL/6J ±  kb
transcript ENSMUST00000109367 Ensembl | MGI Sequence Detail 876 Not Applicable  
polypeptide ENSMUSP00000104992 Ensembl | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 1
    cDNA 26
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38342
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:38212 Jin FY, et al., Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell. 1997 Feb 7;88(3):417-26
  • Latest
    J:338612 Kwiecinska P, et al., Secretory leukocyte protease inhibitor modulates FcepsilonRI-dependent but not Mrgprb2-dependent mastocyte function in psoriasis. Int Immunopharmacol. 2023 Jul 13;122:110631
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory