About   Help   FAQ
Hp1bp3 Gene Detail
Summary
  • Symbol
    Hp1bp3
  • Name
    heterochromatin protein 1, binding protein 3
  • Synonyms
    Hp1bp74, MGC:28927
  • Feature Type
    protein coding gene
  • IDs
    MGI:109369
    NCBI Gene: 15441
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137943781-137971994 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.03 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109369
 protein coding gene Chr4:137943607-137971994 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028990
 protein coding gene Chr4:140929363-140960225 (+)
A/J MGP_AJ_G0028949
 protein coding gene Chr4:134914853-134943181 (+)
AKR/J MGP_AKRJ_G0028901
 protein coding gene Chr4:138764564-138793080 (+)
BALB/cJ MGP_BALBcJ_G0028973
 protein coding gene Chr4:135585565-135615440 (+)
C3H/HeJ MGP_C3HHeJ_G0028687
 protein coding gene Chr4:139112950-139152461 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029414
 protein coding gene Chr4:145939411-145968542 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026685
 protein coding gene Chr4:127898574-127927094 (+)
CAST/EiJ MGP_CASTEiJ_G0028119
 protein coding gene Chr4:137274909-137306662 (+)
CBA/J MGP_CBAJ_G0028652
 protein coding gene Chr4:150086565-150118222 (+)
DBA/2J MGP_DBA2J_G0028801
 protein coding gene Chr4:135289351-135317748 (+)
FVB/NJ MGP_FVBNJ_G0028768
 protein coding gene Chr4:134313481-134341639 (+)
LP/J MGP_LPJ_G0028900
 protein coding gene Chr4:141019140-141047769 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028794
 protein coding gene Chr4:154111232-154142720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029452
 protein coding gene Chr4:139273745-139302143 (+)
PWK/PhJ MGP_PWKPhJ_G0027839
 protein coding gene Chr4:132133482-132167096 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027665
 protein coding gene Chr4:135051045-135079001 (+)
WSB/EiJ MGP_WSBEiJ_G0028197
 protein coding gene Chr4:139503318-139535065 (+)



Homology
more
  • Human Ortholog
    HP1BP3, heterochromatin protein 1 binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HP1BP3, heterochromatin protein 1 binding protein 3
  • Synonyms
    HP1-BP74, HP1BP74
  • Links
    NCBI Gene ID: 50809
    neXtProt AC: NX_Q5SSJ5
    UniProt: Q5SSJ5

  • Chr Location
    1p36.12; chr1:20740266-20787323 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality and reduced body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    20
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15441 NCBI Gene Model | MGI Sequence Detail 28214 C57BL/6J ±  kb
    transcript NR_185235 RefSeq | MGI Sequence Detail 4996 C57BL/6  
    polypeptide Q3TEA8 UniProt | EBI | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000008726 heterochromatin protein 1-binding protein 3
      (term hierarchy)
    • InterPro Domains
      IPR005819 Linker histone H1/H5
      IPR005818 Linker histone H1/H5, domain H15
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q3TEA8 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38414
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory