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Casp7 Gene Detail
Summary
  • Symbol
    Casp7
  • Name
    caspase 7
  • Synonyms
    caspase-7, CMH-1, ICE-IAP3, Mch3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109383
    NCBI Gene: 12369
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56385561-56430776 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1547 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109383
 protein coding gene Chr19:56382640-56430780 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025263
 protein coding gene Chr19:56742971-56790982 (+)
A/J MGP_AJ_G0025239
 protein coding gene Chr19:53939098-53983490 (+)
AKR/J MGP_AKRJ_G0025208
 protein coding gene Chr19:55637838-55685614 (+)
BALB/cJ MGP_BALBcJ_G0025234
 protein coding gene Chr19:54027604-54066860 (+)
C3H/HeJ MGP_C3HHeJ_G0024994
 protein coding gene Chr19:55880342-55924428 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025677
 protein coding gene Chr19:58108280-58153863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023089
 protein coding gene Chr19:52868458-52908248 (+)
CAST/EiJ MGP_CASTEiJ_G0024459
 protein coding gene Chr19:55897443-55937344 (+)
CBA/J MGP_CBAJ_G0024974
 protein coding gene Chr19:60988506-61037465 (+)
DBA/2J MGP_DBA2J_G0025106
 protein coding gene Chr19:53733176-53775675 (+)
FVB/NJ MGP_FVBNJ_G0025067
 protein coding gene Chr19:53436954-53477424 (+)
LP/J MGP_LPJ_G0025192
 protein coding gene Chr19:56611193-56652269 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025100
 protein coding gene Chr19:60289322-60336878 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025735
 protein coding gene Chr19:55855872-55896865 (+)
PWK/PhJ MGP_PWKPhJ_G0024207
 protein coding gene Chr19:53686767-53728816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024010
 protein coding gene Chr19:54528692-54575594 (+)
WSB/EiJ MGP_WSBEiJ_G0024529
 protein coding gene Chr19:55992016-56038646 (+)



Homology
more
  • Human Ortholog
    CASP7, caspase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CASP7, caspase 7
  • Synonyms
    CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3
  • Links
    NCBI Gene ID: 840
    neXtProt AC: NX_P55210
    UniProt: P55210

  • Chr Location
    10q25.3; chr10:113679162-113730909 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CASP7 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation have normal appearance, organ morphology and lymphoid development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    36
  • cDNA Data
    48
  • Literature Summary
    22
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025076 Ensembl Gene Model | MGI Sequence Detail 45216 C57BL/6J ±  kb
transcript ENSMUST00000026062 Ensembl | MGI Sequence Detail 2350 Not Applicable  
polypeptide ENSMUSP00000026062 Ensembl | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    Genomic 1
    cDNA 48
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38428, MGI:2147501
References
more
  • Summaries
    All 123
    Developmental Gene Expression 22
    Gene Ontology 14
    Phenotypes 41
  • Earliest
    J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
  • Latest
    J:342082 Harvest CK, et al., An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2. Nat Commun. 2023 Oct 21;14(1):6686
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory