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Reg3g Gene Detail
Summary
  • Symbol
    Reg3g
  • Name
    regenerating islet-derived 3 gamma
  • Synonyms
    RegIII (gamma)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109406
    NCBI Gene: 19695
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:78443252-78445855 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 34.78 cM, cytoband C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109406
 protein coding gene Chr6:78443252-78445857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030898
 protein coding gene Chr6:79277799-79280402 (-)
A/J MGP_AJ_G0030867
 protein coding gene Chr6:76212317-76214920 (-)
AKR/J MGP_AKRJ_G0030795
 protein coding gene Chr6:78465912-78468515 (-)
BALB/cJ MGP_BALBcJ_G0030877
 protein coding gene Chr6:76270913-76273516 (-)
C3H/HeJ MGP_C3HHeJ_G0030833
 protein coding gene Chr6:105835968-105838571 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031337
 protein coding gene Chr6:81409851-81412454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028524
 protein coding gene Chr6:74986301-74988862 (-)
CAST/EiJ MGP_CASTEiJ_G0029985
 protein coding gene Chr6:78392525-78395124 (-)
CBA/J MGP_CBAJ_G0030564
 protein coding gene Chr6:84609904-84612507 (-)
DBA/2J MGP_DBA2J_G0030717
 protein coding gene Chr6:75576681-75579284 (-)
FVB/NJ MGP_FVBNJ_G0030670
 protein coding gene Chr6:74847164-74849767 (-)
LP/J MGP_LPJ_G0030796
 protein coding gene Chr6:79189879-79192482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030706
 protein coding gene Chr6:88612420-88615023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031361
 protein coding gene Chr6:78281830-78284435 (-)
PWK/PhJ MGP_PWKPhJ_G0029701
 protein coding gene Chr6:74519776-74522387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029529
 protein coding gene Chr6:77102355-77104943 (-)
WSB/EiJ MGP_WSBEiJ_G0030067
 protein coding gene Chr6:78692100-78694703 (-)



Homology
more
  • Human Ortholog
    REG3G, regenerating family member 3 gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REG3G, regenerating family member 3 gamma
  • Synonyms
    LPPM429, PAP-1B, PAP1B, PAP IB, PAPIB, REG III, REG-III, UNQ429
  • Links
    NCBI Gene ID: 130120
    neXtProt AC: NX_Q6UW15
    UniProt: Q6UW15

  • Chr Location
    2p12; chr2:79025686-79028505 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele eshibit increased mucosal bacterial loads, T-helper 1 cells, and intestinal permeability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    61
  • cDNA Data
    52
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030017 Ensembl Gene Model | MGI Sequence Detail 2604 C57BL/6J ±  kb
    transcript ENSMUST00000032089 Ensembl | MGI Sequence Detail 771 Not Applicable  
    polypeptide ENSMUSP00000032089 Ensembl | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR050111 C-type lectin and snaclec domain-containing protein
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 52
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38451, MGI:2141414
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 13
      Gene Ontology 13
      Phenotypes 26
    • Earliest
      J:38547 Narushima Y, et al., Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997 Feb 7;185(2):159-68
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory