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Icam5 Gene Detail
Summary
  • Symbol
    Icam5
  • Name
    intercellular adhesion molecule 5, telencephalin
  • Synonyms
    CD50, Icam3, Tlcn, TLN
  • Feature Type
    protein coding gene
  • IDs
    MGI:109430
    NCBI Gene: 15898
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20943372-20950331 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.70 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109430
 protein coding gene Chr9:20943369-20950332 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034437
 protein coding gene Chr9:18213192-18221810 (+)
A/J MGP_AJ_G0034415
 protein coding gene Chr9:17911122-17918110 (+)
AKR/J MGP_AKRJ_G0034342
 protein coding gene Chr9:18232870-18241665 (+)
BALB/cJ MGP_BALBcJ_G0034406
 protein coding gene Chr9:17805262-17812577 (+)
C3H/HeJ MGP_C3HHeJ_G0034118
 protein coding gene Chr9:18543866-18550777 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034927
 protein coding gene Chr9:18941526-18950362 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031857
 protein coding gene Chr9:17036093-17042823 (+)
CAST/EiJ MGP_CASTEiJ_G0033441
 protein coding gene Chr9:18371001-18377827 (+)
CBA/J MGP_CBAJ_G0034091
 protein coding gene Chr9:19652321-19662116 (+)
DBA/2J MGP_DBA2J_G0034250
 protein coding gene Chr9:17892888-17899815 (+)
FVB/NJ MGP_FVBNJ_G0034193
 protein coding gene Chr9:17402515-17409821 (+)
LP/J MGP_LPJ_G0034335
 protein coding gene Chr9:18386788-18393751 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034236
 protein coding gene Chr9:21274476-21282674 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034947
 protein coding gene Chr9:18182638-18189407 (+)
PWK/PhJ MGP_PWKPhJ_G0033147
 protein coding gene Chr9:17862464-17869239 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032981
 protein coding gene Chr9:18232413-18241130 (+)
WSB/EiJ MGP_WSBEiJ_G0033556
 protein coding gene Chr9:17920062-17926834 (+)



Homology
more
  • Human Ortholog
    ICAM5, intercellular adhesion molecule 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICAM5, intercellular adhesion molecule 5
  • Synonyms
    TLCN, TLN
  • Links
    NCBI Gene ID: 7087
    neXtProt AC: NX_Q9UMF0
    UniProt: Q9UMF0

  • Chr Location
    19p13.2; chr19:10289952-10296778 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit enhanced long-term potentiation, sensorimotor gating, and reward-based learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    7
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15898 NCBI Gene Model | MGI Sequence Detail 6960 C57BL/6J ±  kb
    transcript NM_001410238 RefSeq | MGI Sequence Detail 3023 ZRU/MplStud  
    polypeptide Q60625 UniProt | EBI | MGI Sequence Detail 917 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000001360 intercellular adhesion molecule 5
      (term hierarchy)
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR003988 Intercellular adhesion molecule
      IPR048679 Intercellular adhesion molecule 1/3/5, D2 domain
      IPR013768 Intercellular adhesion molecule, N-terminal
      IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule
      IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
    • GlyGen
      Q60625 16 sites, 27 N-linked glycans (13 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18600, MGD-MRK-38475, MGI:101792
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 40
    • Earliest
      J:38192 Yoshihara Y, et al., An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Neuron. 1994 Mar;12(3):541-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory