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Zfpm1 Gene Detail
Summary
  • Symbol
    Zfpm1
  • Name
    zinc finger protein, multitype 1
  • Synonyms
    Fog1, Friend of GATA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095400
    NCBI Gene: 22761
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123008880-123063990 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.86 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095400
 protein coding gene Chr8:123008595-123064601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034220
 protein coding gene Chr8:125813200-125867828 (+)
A/J MGP_AJ_G0034200
 protein coding gene Chr8:120602742-120658463 (+)
AKR/J MGP_AKRJ_G0034127
 protein coding gene Chr8:124124458-124179027 (+)
BALB/cJ MGP_BALBcJ_G0034194
 protein coding gene Chr8:120804275-120860945 (+)
C3H/HeJ MGP_C3HHeJ_G0033905
 protein coding gene Chr8:124822897-124878199 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034714
 protein coding gene Chr8:129996995-130055963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031656
 protein coding gene Chr8:113431611-113486260 (+)
CAST/EiJ MGP_CASTEiJ_G0033232
 protein coding gene Chr8:124891479-124948888 (+)
CBA/J MGP_CBAJ_G0033878
 protein coding gene Chr8:134803267-134861265 (+)
DBA/2J MGP_DBA2J_G0034034
 protein coding gene Chr8:119797960-119853072 (+)
FVB/NJ MGP_FVBNJ_G0033977
 protein coding gene Chr8:118916963-118979855 (+)
LP/J MGP_LPJ_G0034123
 protein coding gene Chr8:125938808-125995420 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034024
 protein coding gene Chr8:136977888-137033487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034732
 protein coding gene Chr8:124304359-124359021 (+)
PWK/PhJ MGP_PWKPhJ_G0032934
 protein coding gene Chr8:119613316-119668292 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032774
 protein coding gene Chr8:123028707-123083755 (+)
WSB/EiJ MGP_WSBEiJ_G0033348
 protein coding gene Chr8:125056419-125112053 (+)



Homology
more
  • Human Ortholog
    ZFPM1, zinc finger protein, FOG family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFPM1, zinc finger protein, FOG family member 1
  • Synonyms
    FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A
  • Links
    NCBI Gene ID: 161882
    neXtProt AC: NX_Q8IX07
    UniProt: Q8IX07

  • Chr Location
    16q24.2; chr16:88451769-88537031 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have poorly vascularized yolk sacs and small, pale livers. Mutants die between embryonic days 10.5 and 12.5 with severe anemia associated with a block in megakaryocyte development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    131
  • cDNA Data
    8
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049577 Ensembl Gene Model | MGI Sequence Detail 55111 C57BL/6J ±  kb
    transcript ENSMUST00000054052 Ensembl | MGI Sequence Detail 3390 Not Applicable  
    polypeptide ENSMUSP00000058037 Ensembl | MGI Sequence Detail 995 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 8
      Primer pair 6
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 25
      Gene Ontology 19
      Phenotypes 18
    • Earliest
      J:13573 LaRosa GJ, et al., Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox. Mol Cell Biol. 1988 Sep;8(9):3906-17
    • Latest
      J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory