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Sf1 Gene Detail
Summary
  • Symbol
    Sf1
  • Name
    splicing factor 1
  • Synonyms
    CW17R, MZFM, WBP4, Zfp162
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095403
    NCBI Gene: 22668
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6413952-6428060 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.48 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095403
 protein coding gene Chr19:6413720-6428060 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024761
 protein coding gene Chr19:3414506-3430211 (+)
A/J MGP_AJ_G0024727
 protein coding gene Chr19:3228881-3243221 (+)
AKR/J MGP_AKRJ_G0024700
 protein coding gene Chr19:3326568-3340908 (+)
BALB/cJ MGP_BALBcJ_G0024727
 protein coding gene Chr19:3227206-3241708 (+)
C3H/HeJ MGP_C3HHeJ_G0024495
 protein coding gene Chr19:3347357-3361729 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025173
 protein coding gene Chr19:3468309-3482649 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022607
 protein coding gene Chr19:3152490-3166856 (+)
CAST/EiJ MGP_CASTEiJ_G0023967
 protein coding gene Chr19:3371525-3387389 (+)
CBA/J MGP_CBAJ_G0024467
 protein coding gene Chr19:3640449-3654981 (+)
DBA/2J MGP_DBA2J_G0024594
 protein coding gene Chr19:3218281-3232717 (+)
FVB/NJ MGP_FVBNJ_G0024560
 protein coding gene Chr19:3234706-3249254 (+)
LP/J MGP_LPJ_G0024680
 protein coding gene Chr19:3382463-3396802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024589
 protein coding gene Chr19:3462598-3476929 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025221
 protein coding gene Chr19:3352209-3366545 (+)
PWK/PhJ MGP_PWKPhJ_G0023713
 protein coding gene Chr19:3252308-3267056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023518
 protein coding gene Chr19:3311598-3325933 (+)
WSB/EiJ MGP_WSBEiJ_G0024029
 protein coding gene Chr19:3365835-3380174 (+)



Homology
more
  • Human Ortholog
    SF1, splicing factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SF1, splicing factor 1
  • Synonyms
    BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162
  • Links
    NCBI Gene ID: 7536
    neXtProt AC: NX_Q15637
    UniProt: Q15637

  • Chr Location
    11q13.1; chr11:64764606-64778786 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trapped allele exhibit embryonic lethalilty prior to E8.5. Mice heterozygous for a gene trapped allele exhibit increased incidence of chemically induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    95
  • cDNA Data
    234
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22668 NCBI Gene Model | MGI Sequence Detail 14109 C57BL/6J ±  kb
    transcript NM_001403448 RefSeq | MGI Sequence Detail 4125 C57BL/6  
    polypeptide Q64213 UniProt | EBI | MGI Sequence Detail 653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 242
      Genomic 4
      cDNA 234
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147764
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 15
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:302708 Liu HB, et al., RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Adv Sci (Weinh). 2019 Aug 7;6(15):1900295
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory