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Sycp3 Gene Detail
Summary
  • Symbol
    Sycp3
  • Name
    synaptonemal complex protein 3
  • Synonyms
    Cor1, Scp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109542
    NCBI Gene: 20962
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:88295449-88309098 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 43.94 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109542
 protein coding gene Chr10:88295431-88309098 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017628
 protein coding gene Chr10:89545440-89561953 (+)
A/J MGP_AJ_G0017607
 protein coding gene Chr10:86519519-86533199 (+)
AKR/J MGP_AKRJ_G0017565
 protein coding gene Chr10:88981428-88995082 (+)
BALB/cJ MGP_BALBcJ_G0017570
 protein coding gene Chr10:86802254-86817833 (+)
C3H/HeJ MGP_C3HHeJ_G0017393
 protein coding gene Chr10:88957020-88970633 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018027
 protein coding gene Chr10:92559737-92574690 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015709
 protein coding gene Chr10:82291125-82304704 (+)
CAST/EiJ MGP_CASTEiJ_G0016958
 protein coding gene Chr10:88880761-88896833 (+)
CBA/J MGP_CBAJ_G0017362
 protein coding gene Chr10:96386533-96402226 (+)
DBA/2J MGP_DBA2J_G0017468
 protein coding gene Chr10:85640849-85654742 (+)
FVB/NJ MGP_FVBNJ_G0017460
 protein coding gene Chr10:84864557-84878223 (+)
LP/J MGP_LPJ_G0017542
 protein coding gene Chr10:90214716-90232348 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017491
 protein coding gene Chr10:97882360-97891596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018064
 protein coding gene Chr10:88817041-88831051 (+)
PWK/PhJ MGP_PWKPhJ_G0016739
 protein coding gene Chr10:85662171-85678275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016526
 protein coding gene Chr10:87558964-87572507 (+)
WSB/EiJ MGP_WSBEiJ_G0017017
 protein coding gene Chr10:88798873-88818557 (+)



Homology
more
  • Human Ortholog
    SYCP3, synaptonemal complex protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYCP3, synaptonemal complex protein 3
  • Synonyms
    COR1, RPRGL4, SCP3, SPGF4
  • Links
    NCBI Gene ID: 50511
    neXtProt AC: NX_Q8IZU3
    UniProt: Q8IZU3

  • Chr Location
    12q23.2; chr12:101728648-101739472 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sycp3 mouse models; 1 with human SYCP3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are male infertile and female sub-fertile. Reduced litter size in females is due to achiasmatic oocytes, resulting in aneuploidy and embryonic death. Meiosis in males blocks at early prophase with lack of synaptonemal complexes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    58
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1438
  • Tissues
    79
  • cDNA Data
    9
  • Literature Summary
    233
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20962 NCBI Gene Model | MGI Sequence Detail 13650 C57BL/6J ±  kb
    transcript NM_011517 RefSeq | MGI Sequence Detail 1132 C57BL/6  
    polypeptide P70281 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 2
      cDNA 11
      Primer pair 13
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39541
    References
    more
    • Summaries
      All 355
      Developmental Gene Expression 233
      Diseases 1
      Gene Ontology 58
      Phenotypes 43
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory