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Ackr3 Gene Detail
Summary
  • Symbol
    Ackr3
  • Name
    atypical chemokine receptor 3
  • Synonyms
    Cmkor1, Cxcr7, Rdc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109562
    NCBI Gene: 12778
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:90131702-90143446 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 45.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109562
 protein coding gene Chr1:90131702-90144473 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016294
 protein coding gene Chr1:91680073-91692832 (+)
A/J MGP_AJ_G0016275
 protein coding gene Chr1:88404926-88417700 (+)
AKR/J MGP_AKRJ_G0016236
 protein coding gene Chr1:91015901-91028661 (+)
BALB/cJ MGP_BALBcJ_G0016231
 protein coding gene Chr1:88564871-88577645 (+)
C3H/HeJ MGP_C3HHeJ_G0016060
 protein coding gene Chr1:91225138-91237909 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016690
 protein coding gene Chr1:95233942-95246709 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014408
 protein coding gene Chr1:82686821-82699439 (+)
CAST/EiJ MGP_CASTEiJ_G0015645
 protein coding gene Chr1:90553735-90565412 (+)
CBA/J MGP_CBAJ_G0016036
 protein coding gene Chr1:98279630-98292398 (+)
DBA/2J MGP_DBA2J_G0016139
 protein coding gene Chr1:87633616-87646390 (+)
FVB/NJ MGP_FVBNJ_G0016138
 protein coding gene Chr1:86648553-86661304 (+)
LP/J MGP_LPJ_G0016210
 protein coding gene Chr1:92822193-92834954 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016163
 protein coding gene Chr1:101548815-101561586 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016730
 protein coding gene Chr1:91040346-91053101 (+)
PWK/PhJ MGP_PWKPhJ_G0015429
 protein coding gene Chr1:87025257-87038008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015212
 protein coding gene Chr1:89953691-89965307 (+)
WSB/EiJ MGP_WSBEiJ_G0015703
 protein coding gene Chr1:90774784-90787533 (+)



Homology
more
  • Human Ortholog
    ACKR3, atypical chemokine receptor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACKR3, atypical chemokine receptor 3
  • Synonyms
    CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1
  • Links
    NCBI Gene ID: 57007
    neXtProt AC: NX_P25106
    UniProt: P25106

  • Chr Location
    2q37.3; chr2:236537122-236582354 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 9 alleles in 9 genetic backgrounds
    3 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous null mutations result in perinatal lethality with cardiac defects including semilunar valve defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1097
  • Tissues
    138
  • cDNA Data
    11
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12778 NCBI Gene Model | MGI Sequence Detail 11745 C57BL/6J ±  kb
    transcript NM_001271607 RefSeq | MGI Sequence Detail 2321 ZRU/MplStud  
    polypeptide P56485 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 12
      Primer pair 1
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39561, MGI:2138598
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 50
      Gene Ontology 10
      Phenotypes 57
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354184 Pineiro-Sabaris R, et al., Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve. Dis Model Mech. 2024 Sep 1;17(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory