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Pld1 Gene Detail
Summary
  • Symbol
    Pld1
  • Name
    phospholipase D1
  • Synonyms
    Pld1a, Pld1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109585
    NCBI Gene: 18805
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27992844-28187511 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 11.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6107 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109585
 protein coding gene Chr3:27992636-28187511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027114
 protein coding gene Chr3:25316777-25506214 (+)
A/J MGP_AJ_G0027074
 protein coding gene Chr3:25089954-25268485 (+)
AKR/J MGP_AKRJ_G0027043
 protein coding gene Chr3:25427421-25616613 (+)
BALB/cJ MGP_BALBcJ_G0027086
 protein coding gene Chr3:24774048-24952322 (+)
C3H/HeJ MGP_C3HHeJ_G0026827
 protein coding gene Chr3:25475343-25659126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027531
 protein coding gene Chr3:26692625-26889490 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024893
 protein coding gene Chr3:23086893-23272045 (+)
CAST/EiJ MGP_CASTEiJ_G0026282
 protein coding gene Chr3:25307971-25545121 (+)
CBA/J MGP_CBAJ_G0026805
 protein coding gene Chr3:27415478-27601418 (+)
DBA/2J MGP_DBA2J_G0026939
 protein coding gene Chr3:24636988-24816097 (+)
FVB/NJ MGP_FVBNJ_G0026907
 protein coding gene Chr3:24109468-24298155 (+)
LP/J MGP_LPJ_G0027051
 protein coding gene Chr3:25987005-26171996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026928
 protein coding gene Chr3:29962750-30159402 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027591
 protein coding gene Chr3:25163216-25353351 (+)
PWK/PhJ MGP_PWKPhJ_G0026015
 protein coding gene Chr3:24117997-24309254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025825
 protein coding gene Chr3:24688452-24895467 (+)
WSB/EiJ MGP_WSBEiJ_G0026356
 protein coding gene Chr3:25215078-25406422 (+)



Homology
more
  • Human Ortholog
    PLD1, phospholipase D1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLD1, phospholipase D1
  • Synonyms
    CVDD, CVDP1
  • Links
    NCBI Gene ID: 5337
    neXtProt AC: NX_Q13393
    UniProt: Q13393

  • Chr Location
    3q26.31; chr3:171600404-171810950 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show reduced tumor growth and angiogenesis. Homozygotes for a second null allele show abnormal hepatic autophagy after food restriction. Homozygotes for a third null allele show altered platelet activation and protection from thrombosis and ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    163
  • cDNA Data
    53
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027695 Ensembl Gene Model | MGI Sequence Detail 194668 C57BL/6J ±  kb
    transcript ENSMUST00000123539 Ensembl | MGI Sequence Detail 3732 Not Applicable  
    polypeptide ENSMUSP00000118727 Ensembl | MGI Sequence Detail 1074 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-39584, MGI:2139589, MGI:2140090
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 51
    • Earliest
      J:38674 Hammond SM, et al., Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem. 1997 Feb 7;272(6):3860-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory