About   Help   FAQ
Srgap2 Gene Detail
Summary
  • Symbol
    Srgap2
  • Name
    SLIT-ROBO Rho GTPase activating protein 2
  • Synonyms
    9930124L22Rik, FBP2, Fnbp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109605
    NCBI Gene: 14270
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131212989-131455090 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.93 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4061 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109605
 protein coding gene Chr1:131212989-131455269 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016453
 protein coding gene Chr1:134708829-134958570 (-)
A/J MGP_AJ_G0016436
 protein coding gene Chr1:129734691-129969285 (-)
AKR/J MGP_AKRJ_G0016401
 protein coding gene Chr1:133547447-133782047 (-)
BALB/cJ MGP_BALBcJ_G0016396
 protein coding gene Chr1:130062230-130296493 (-)
C3H/HeJ MGP_C3HHeJ_G0016222
 protein coding gene Chr1:133684720-133925261 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016857
 protein coding gene Chr1:139720314-139980912 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014571
 protein coding gene Chr1:122868079-123108960 (-)
CAST/EiJ MGP_CASTEiJ_G0015802
 protein coding gene Chr1:132683728-132923637 (-)
CBA/J MGP_CBAJ_G0016194
 protein coding gene Chr1:144524550-144771921 (-)
DBA/2J MGP_DBA2J_G0016301
 protein coding gene Chr1:128699921-128935321 (-)
FVB/NJ MGP_FVBNJ_G0016300
 protein coding gene Chr1:127329433-127564823 (-)
LP/J MGP_LPJ_G0016372
 protein coding gene Chr1:136026863-136271136 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016325
 protein coding gene Chr1:150288630-150539688 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016893
 protein coding gene Chr1:133312061-133548051 (-)
PWK/PhJ MGP_PWKPhJ_G0015588
 protein coding gene Chr1:127656057-127893829 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015375
 protein coding gene Chr1:132243809-132485715 (-)
WSB/EiJ MGP_WSBEiJ_G0015864
 protein coding gene Chr1:133294279-133533765 (-)



Homology
more
  • Human Ortholog
    SRGAP2, SLIT-ROBO Rho GTPase activating protein 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRGAP2, SLIT-ROBO Rho GTPase activating protein 2
  • Synonyms
    ARHGAP34, FNBP2, SRGAP2A, SRGAP3
  • Links
    NCBI Gene ID: 23380
    neXtProt AC: NX_O75044
    UniProt: O75044

  • Chr Location
    1q32.1; chr1:206203346-206464436 (+)  GRCh38
  • Human Ortholog
    SRGAP2B, SLIT-ROBO Rho GTPase activating protein 2B
  • Synonyms
    SRGAP2L, SRGAP2P2
  • Links
    NCBI Gene ID: 647135
    UniProt: P0DMP2

  • Chr Location
    1q21.1; chr1:144887265-145095528 (-)  GRCh38
  • Human Ortholog
    SRGAP2C, SLIT-ROBO Rho GTPase activating protein 2C
  • Synonyms
    SRGAP2P1
  • Links
    NCBI Gene ID: 653464
    neXtProt AC: NX_P0DJJ0
    UniProt: P0DJJ0

  • Chr Location
    1p11.2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele are born at below the expected Mendelian ratio, but are otherwise viable. Layer 5 cortical pyramidal neurons exhibit an increased density of dendritic spines with a decreased spine head width and increased length of spine necks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    974
  • Tissues
    163
  • cDNA Data
    158
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026425 Ensembl Gene Model | MGI Sequence Detail 242102 C57BL/6J ±  kb
transcript ENSMUST00000097588 Ensembl | MGI Sequence Detail 8026 Not Applicable  
polypeptide ENSMUSP00000095195 Ensembl | MGI Sequence Detail 1071 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 160
    cDNA 158
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-39604, MGI:2138246
References
more
  • Summaries
    All 65
    Developmental Gene Expression 12
    Gene Ontology 13
    Phenotypes 17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:358151 Assendorp N, et al., CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny. Cell Rep. 2024 Oct 22;43(10):114797
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory