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Aip Gene Detail
Summary
  • Symbol
    Aip
  • Name
    aryl-hydrocarbon receptor-interacting protein
  • Synonyms
    Ara9, D19Bwg1412e, Fkbp16, Xap2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109622
    NCBI Gene: 11632
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4164446-4175858 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109622
 protein coding gene Chr19:4163756-4177233 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024647
 protein coding gene Chr19:947342-961020 (-)
A/J MGP_AJ_G0024613
 protein coding gene Chr19:916443-927793 (-)
AKR/J MGP_AKRJ_G0024586
 protein coding gene Chr19:940620-952026 (-)
BALB/cJ MGP_BALBcJ_G0024613
 protein coding gene Chr19:904569-915886 (-)
C3H/HeJ MGP_C3HHeJ_G0024381
 protein coding gene Chr19:934806-946190 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025061
 protein coding gene Chr19:982239-999501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022490
 protein coding gene Chr19:858372-869997 (-)
CAST/EiJ MGP_CASTEiJ_G0023853
 protein coding gene Chr19:942559-955940 (-)
CBA/J MGP_CBAJ_G0024352
 protein coding gene Chr19:1043438-1057734 (-)
DBA/2J MGP_DBA2J_G0024480
 protein coding gene Chr19:875417-886703 (-)
FVB/NJ MGP_FVBNJ_G0024447
 protein coding gene Chr19:883708-896940 (-)
LP/J MGP_LPJ_G0024566
 protein coding gene Chr19:942608-955585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024477
 protein coding gene Chr19:992484-1005675 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025108
 protein coding gene Chr19:935426-948556 (-)
PWK/PhJ MGP_PWKPhJ_G0023599
 protein coding gene Chr19:926525-938389 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023404
 protein coding gene Chr19:918588-929613 (-)
WSB/EiJ MGP_WSBEiJ_G0023915
 protein coding gene Chr19:924479-935765 (-)



Homology
more
  • Human Ortholog
    AIP, aryl hydrocarbon receptor interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AIP, aryl hydrocarbon receptor interacting protein
  • Synonyms
    ARA9, FKBP16, FKBP37, PITA1, SMTPHN, XAP-2, XAP2
  • Links
    NCBI Gene ID: 9049
    neXtProt AC: NX_O00170
    UniProt: O00170

  • Chr Location
    11q13.2; chr11:67468174-67491154 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AIP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotypes from multigenic genotypes
    7 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality from E10 to E19. Mice exhibit cardiac malformations such as double outlet right ventricle and ventricular septal defect and sometimes hemorrhage or petechiae. Mice homozygous for a hypomorphic allele exhibit patent ductus venosus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    55
  • cDNA Data
    91
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024847 Ensembl Gene Model | MGI Sequence Detail 11413 C57BL/6J ±  kb
    transcript ENSMUST00000025767 Ensembl | MGI Sequence Detail 1261 Not Applicable  
    polypeptide ENSMUSP00000025767 Ensembl | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003875 AH receptor-interacting protein
      (term hierarchy)
    • PDB
      8H77
    • InterPro Domains
      IPR039663 AIP/AIPL1/TTC9
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    • GlyGen
      O08915 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 91
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33944, MGD-MRK-39621, MGI:106252, MGI:2147439, MGI:2147730
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:39465 Ma Q, et al., A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1997 Apr 4;272(14):8878-84
    • Latest
      J:316386 Garcia-Rendueles AR, et al., RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas. Oncogene. 2021 Nov;40(45):6354-6368
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory