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Axin1 Gene Detail
Summary
  • Symbol
    Axin1
  • Name
    axin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096327
    NCBI Gene: 12005
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26357662-26414785 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.07 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1124 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096327
 protein coding gene Chr17:26350294-26414785 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023392
 protein coding gene Chr17:25275583-25342983 (+)
A/J MGP_AJ_G0023351
 protein coding gene Chr17:24529234-24587023 (+)
AKR/J MGP_AKRJ_G0023317
 protein coding gene Chr17:24637771-24698072 (+)
BALB/cJ MGP_BALBcJ_G0023356
 protein coding gene Chr17:24749090-24808297 (+)
C3H/HeJ MGP_C3HHeJ_G0023116
 protein coding gene Chr17:25028809-25090311 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023798
 protein coding gene Chr17:26344722-26406631 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021274
 protein coding gene Chr17:21986036-22046012 (+)
CAST/EiJ MGP_CASTEiJ_G0022618
 protein coding gene Chr17:24930895-24998081 (+)
CBA/J MGP_CBAJ_G0023091
 protein coding gene Chr17:27275084-27342697 (+)
DBA/2J MGP_DBA2J_G0023221
 protein coding gene Chr17:24123145-24180349 (+)
FVB/NJ MGP_FVBNJ_G0023191
 protein coding gene Chr17:23884199-23942822 (+)
LP/J MGP_LPJ_G0023298
 protein coding gene Chr17:25561415-25621640 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023210
 protein coding gene Chr17:26845670-26912735 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023838
 protein coding gene Chr17:24985941-25048492 (+)
PWK/PhJ MGP_PWKPhJ_G0022367
 protein coding gene Chr17:22891208-22950783 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022185
 protein coding gene Chr17:23050832-23115322 (+)
WSB/EiJ MGP_WSBEiJ_G0022681
 protein coding gene Chr17:25010305-25069908 (+)



Homology
more
  • Human Ortholog
    AXIN1, axin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AXIN1, axin 1
  • Synonyms
    AXIN, CMDOH, PPP1R49
  • Links
    NCBI Gene ID: 8312
    neXtProt AC: NX_O15169
    UniProt: O15169

  • Chr Location
    16p13.3; chr16:287440-352723 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human AXIN1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 7 alleles in 15 genetic backgrounds
    20 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    167
  • GO References
    52
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    119
  • cDNA Data
    110
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024182 Ensembl Gene Model | MGI Sequence Detail 57124 C57BL/6J ±  kb
    transcript ENSMUST00000074370 Ensembl | MGI Sequence Detail 3777 Not Applicable  
    polypeptide ENSMUSP00000073974 Ensembl | MGI Sequence Detail 863 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 123
      cDNA 113
      Primer pair 9
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 29
      Gene Ontology 52
      Phenotypes 49
    • Earliest
      J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
    • Latest
      J:347054 Zhang CS, et al., The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab. 2022 Oct;4(10):1369-1401
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory